New research on Cinnulin PF was recently performed at the School of Medicine, University of Maryland, and presented at the Experimental Biology Conference in Boston. Cinnulin PF is the original clinically tested cinnamon extract standardized to bioactive type A polymers. It is known that oxidative stress contributes to blood vessel wall damage, which reduces the efficiency of circulation to the brain. Vascular endothelium is important to cardiovascular health including blood pressure. In addition, cerebral vascular function is important to cognitive function and cerebral blood flow.
Cinnulin PF has been shown to have powerful antioxidant properties in human, animal and in vitro studies. This study evaluated its effects on oxygen glucose deprivation of cells similar to those of the microscopic blood vessels in the brain. Cinnulin PF reversed the negative effects of oxygen glucose deprivation and had positive effects related to blood vessel dilation and inflammatory response. Oxygen glucose deprivation decreases the glucose uptake of brain microvascular endothelial cells, and Cinnulin PF enhances the impaired glucose uptake.
One possible mechanism by which Cinnulin PF may attenuate endothelial cell function and glucose uptake is through SIRT1. SIRT1 is a protein shown to have multiple effects on aging, blood sugar and obesity. In conclusion, Cinnulin PF was shown to have positive effects against oxidative damage and is believed to be beneficial to support against oxidative stress throughout the body, including the circulatory system and the brain.