Nutrition 21 LLC is proud to announce the presentation of new clinical study results supporting Nitrosigine™ inositol-stabilized arginine silicate, titled, “A Clinical Evaluation to Determine the Safety, Pharmacokinetics and Pharmacodynamics of an Inositol-Stabilized Arginine Silicate Dietary Supplement in Healthy Adult Males.” The study was presented to scientists and other professionals at the acclaimed Experimental Biology 2014 annual meeting’s poster session and will be published in the Federation of American Societies for Experimental Biology Journal (FASEB).
The clinical study demonstrated significant increases in plasma arginine levels (P<0.01) and serum silicon levels (P<0.01) after a single dose of Nitrosigine. In addition, a significant increase in nitric oxide levels (measured as salivary nitrites) was seen after 14 days of product consumption (P<0.05). The results of the clinical study support the use of Nitrosigine as a bioavailable source of arginine and silicon, validating the preclinical studies and confirming Nitrosigine as an effective ingredients in products for sports nutrition, men’s health and cardiovascular health.
The clinical study that verified daily Nitrosigine supplementation increased nitric oxide (NO) levels with a significant change in NO levels between the first treatment visit and after 14 days. The increase in NO levels can promote relaxation of smooth muscle in blood vessels, which increases blood flow and improves cardiovascular and muscular health.
Primary author, Douglas S. Kalman, PhD, RD, CCRC, FACN, director BD, nutrition and applied clinical trials at Miami Research Associates, stated, “Nitrosigine, a new arginine-based molecule, has early and preliminary research that is deserving of further development.”
James Komorowski, MS, CNS, vice president of scientific and regulatory affairs of Nutrition 21, commented, “We are immensely pleased with the new clinical results. The clinical study confirms our pre-clinical work, and supports Nitrosigine’s ability to optimize the benefits of rigorous workouts by significantly increasing nitric oxide levels. Fitness-focused customers who want to get the most out of their training regimen, will appreciate that Nitrosigine is quickly absorbed by the body, taking effect in 30 minutes and lasting up to three hours. Nitrosigine has also been shown to significantly raise arginine and silicon levels - both important nutrients for cardiovascular performance.”
- Consumer benefits directly linked to the clinical study findings include:
- Nitrosigine significantly enhances nitric oxide levels
- Nitrosigine is a safe, bioavailable source of arginine and silicon
- Nitrosigine significantly increases plasma arginine levels in 30 minutes
- Nitrosigine significantly increases plasma arginine levels for up to 3 hours
- Nitrosigine significantly increases silicon levels for up to 1.5 hours
“Nutrition 21 is thrilled to have the human clinical study available as support for our NDI-accepted, Nitrosigine. Based on clinical and pre-clinical results, Nitrosigine demonstrates superiority over arginine as shown by increases in blood flow markers and silicon absorption. Nitrosigine is currently available in the retail channel in products such as, SuperPump® 3.0 and Razor8® and is in development in other finished goods. We anticipate continued high market interest with robust customer sales,” said Jim Kahn, executive director of national sales at Nutrition 21.