Evidence-based Products

Study Claim: 100mg Activin in rats for three weeks resulted in improved cardiac recovery following ischemia.

Published: Pataki T, et al. Grape seed proanthocyanidins improved cardiac recovery during reperfusion after ischemia in isolated rat hearts. Am J Clin Nutr 2002 May;75(5):894-9.

Abstract: Researchers fed one group of rats different doses of grape seed (Vitis vinifera) proanthocyanidin-rich extract for three weeks; the control group was not treated. They anaesthetised the animals, isolated the hearts and subjected them to 30 minutes of ischemia, followed by two hours of reperfusion.

In the rats treated with 50mg and 100mg proanthocyanidins/kg, the incidence of reperfusion-induced ventricular fibrillation was significantly reduced, by 42 per cent and 25 per cent, respectively, compared with the control group. In rats treated with 100mg proanthocyanidins/kg, the recovery of coronary flow, aortic flow and developed pressure after 60 minutes of reperfusion improved 32 per cent, 98 per cent and 37 per cent, respectively, compared with the untreated rats. Tests showed that 100mg proanthocyanidins inhibited the formation of oxygen free radicals by 75 per cent compared with the control group.

Potential Applications: Activin, which is GRAS, can be used as a dietary supplement and added to functional foods to enhance cardiovascular health.

More Info:
Dry Creek Nutrition Inc, USA
Tel: +1 209 341 5696
Study Claim: Ten men who took 2g L-CarniPure for three weeks showed rapid recovery from high-intensity exercise.

Published: Volek JS, et al. L-carnitine L-tartrate supplementation favorably affects markers of recovery from exercise stress. Am J Physiol Endocrinol Metab 2002; 282:E474-E482.

Abstract: Researchers at Ball State University, Indiana, studied 10 resistance-trained men, who consumed either 2g L-carnitine L-tartrate (LCLT)/day or placebo for three weeks, before obtaining blood samples on six consecutive days, before and after squat exercises. LCLT significantly attenuated exercise-induced increases in plasma markers of purine catabolism and circulating cytosolic proteins. Exercise-induced increases in plasma malondialde-hyde returned to resting values sooner during LCLT compared with placebo. The amount of muscle disruption, measured by MRI scans during LCLT, was 41 per cent to 45 per cent of the placebo area. These results indicate LCLT supplementation is effective in assisting recovery from high-repetition squat exercises.

Potential Applications: L-carnitine L-tartrate is suitable for capsules, tablets and bars, as well as for liquid applications, such as syrups, beverages and ampoules. The product is aimed at athletes, the active elderly and overweight people.

More Info:
Lonza Group, USA
Tel: +1 201 794 2400,

Study Claim: 80mg Promensil for 16 weeks decreased by 44 per cent hot flushes in 30 menopausal women.

Published: van de Weijer PHM, Barentsen R. Isoflavones from red clover (Promensil) significantly reduce meno-pausal hot flush symptoms compared with placebo. Maturitas 2002;42:187-93.

Abstract: In this randomised, double-blind, placebo-controlled trial, 30 women with more than 12 months amenorrhoea and experiencing more than five flushes per day took single-blind placebo tablets for four weeks. They were then randomised to either placebo or 80mg isoflavones for another 12 weeks. Researchers measured decreases in the number of hot flushes per day and changes in the Greene Climacteric Scale score.

During the first four weeks of placebo, the frequency of hot flushes decreased by 16 per cent. During the subsequent double-blind phase, researchers found a 44 per cent, statistically significant decrease in the group taking Promensil, whereas there was no further reduction in the placebo group.

Potential Applications: Promensil is a finished product that is intended for women experiencing menopausal symptoms.

More Info:
Novogen Ltd, Australia
Tel: +612 9878 0088

To submit recently published research on your company's ingredients, please E-mail [email protected] for details.

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