Research capsule: DSM's Resvida, Kyowa Hakko's Sustamine

Research capsule: DSM's Resvida, Kyowa Hakko's Sustamine

A selection of published research on ingredients in the natural products industry for the December 2010 issue of Functional Ingredients magazine.

VITAL STATS: DSM's Resvida™ is scientifically proven, high-performance resveratrol.

STUDY CLAIM: Acute resveratrol supplementation can improve a key marker of blood flow and thereby overall cardiovascular health.

PUBLISHED: Wong, R.H. et al. Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure. Nutr Metab Cardiovasc Dis. 2010 Jul 29.

ABSTRACT: Flow-mediated dilatation of the brachial artery (FMD) is a biomarker of endothelial function and cardiovascular health. Impaired FMD is associated with several cardiovascular risk factors including hypertension and obesity. Various food ingredients such as polyphenols have been shown to improve FMD. The researchers investigated whether consuming resveratrol, a polyphenol found in red wine, can enhance FMD acutely and whether there is a dose-response relationship for this effect.

In the study 19 overweight/obese (BMI 25-35 kg m(-2)) men or post-menopausal women with untreated borderline hypertension (systolic BP: 130-160 mmHg or diastolic BP: 85-100 mmHg) consumed three doses of resveratrol (resVida 30, 90 and 270 mg) and a placebo at weekly intervals in a double-blind, randomized crossover comparison. One hour after consumption of the supplement, plasma resveratrol and FMD were measured. Data were analyzed by linear regression versus log(10) dose of resveratrol. Fourteen men and five women (age 55 +/- 2 years, BMI 28.7 +/- 0.5 kg m(-2), BP 141 +/- 2/89 +/- 1 mmHg) completed this study. There was a significant dose effect of resveratrol on plasma resveratrol concentration (P < 0.001) and on FMD (P < 0.01), which increased from 4.1 +/- 0.8% (placebo) to 7.7 +/- 1.5% after 270 mg resveratrol. FMD was also linearly related to log(10) plasma resveratrol concentration (P < 0.01).

The researchers concluded that acute resveratrol consumption increased plasma resveratrol concentrations and FMD in a dose-related manner. This effect may contribute to the purported cardiovascular health benefits of grapes and red wine.

APPLICATIONS: ResVida's comprehensive safety profile makes it suitable various dietary supplements and food products.


VITAL STATS: Kyowa Hakko's Sustamine brand L-alanyl-L-glutamine

STUDY CLAIM: Ingestion of L-alanyl-Lglutamine ingestion during hydration stress in endurance exercise leads to a significantly increased time to exhaustion.

PUBLISHED: Jay R Hoffman, et al. Examination of the efficacy of acute L-alanyl-L-glutamine ingestion during hydration stress in endurance exercise. J Int Soc Sports Nutr. 2010 Feb 3;7:8

ABSTRACT: The effect of acute L-alanyl-L-glutamine (AG; Sustamine™) ingestion on performance changes and markers of fluid regulation, immune, inflammatory, oxidative stress, and recovery was examined in response to exhaustive endurance exercise, during and in the absence of dehydration. Ten physically active young male subjects reported to the laboratory in a euhydrated state to provide a baseline (BL) blood draw and perform a maximal exercise test. In the four subsequent randomly ordered trials, subjects dehydrated to -2.5% of their baseline body mass. For T2, subjects achieved their goal weight and were not rehydrated. During T3 - T5, subjects reached their goal weight and then rehydrated to 1.5% of their baseline body mass by drinking either water (T3) or two different doses (T4 and T5) of the AG supplement (0.05 g·kg-1 and 0.2 g·kg-1, respectively). Subjects then exercised 75 percent of their VO2 max on a cycle ergometer. During T2 - T5 blood draws occurred once goal body mass was achieved (DHY), immediately prior to the exercise stress (RHY), and immediately following the exercise protocol (IP). Resting 24 hour (24P) blood samples were also obtained. Blood samples were analyzed for glutamine, potassium, sodium, aldosterone, arginine vasopressin (AVP), C-reactive protein (CRP), interleukin-6 (IL-6), malondialdehyde (MDA),testosterone, cortisol, ACTH, growth hormone and creatine kinase.

Results showed glutamine concentrations for T5 were significantly higher at RHY and IP than T2 - T4. When examining performance changes (difference between T2 - T5 and T1), significantly greater times to exhaustion occurred during T4 (130.2 ± 340.2 sec) and T5 (157.4 ± 263.1 sec) compared to T2 (455.6 ± 245.0 sec). Plasma sodium concentrations were greater (p < 0.05) at RHY and IP for T2 than all other trials. Aldosterone concentrations at RHY and IP were significantly lower than that at BL and DHY. AVP was significantly elevated at DHY, RHY and IP compared to BL measures. No significant differences were observed between trials in CRP, IL-6, MDA, or in any of the other hormonal or biochemical measures. Results demonstrate that AG supplementation significantly increased the time to exhaustion during a mild hydration stress.

APPLICATIONS: Sports nutrition supplements, beverages
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