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Active Communications International Presents sports Nutrition for Health & Performance Conference

CHICAGO — ACI’s Sports Nutrition for Health & Performance conference, being held October 24-25, 2002, at Pointe Hilton Tapatio Cliffs Resort in Phoenix, Arizona, will be a two-day event where attendees will learn how to educate and broaden the consumer segment of the sports nutritional products market. This conference will also feature a pre-conference golf outing at Pointe Hilton Tapatio Cliffs Resort on Wednesday, October 23, 2002.

The event is hosted by conference production company Active Communications International, Inc. (ACI) and is in association with NPI Center, Nutrition Business Journal, National Nutritional Foods Association, Nutritional Outlook, Virgo Publishing Natural Products Division, Nutraceutical World magazine and Food Processing’s Wellness Foods magazine.

Sports Nutrition for Health & Performance was designed for executives, consultants and researchers in the areas of: product development, marketing, science and technology, nutrition, regulatory/legal affairs, public relations, sales, brand management and new business development. The speaking panel includes such industry leaders as Cargill, Metabolife, SoBe, Chemi Nutraceuticals and Blue Pacific Flavors.

Attendees will learn how to:

  • Evaluate the “performance utility” and its broadening appeal - - -beyond that of the athlete to include fitness enthusiasts and wellness consumers
  • Understand the social, regulatory and technological factors that either promote or hinder the development and marketing of various types of sports nutrition products
  • Describe various types of foods/drinks and supplements that are marketed as “lifestyle solutions” - - - meeting the needs, personal preferences and interests of today’s Baby Boomers and Generation Xer’s
  • Realize the importance of continuously educating the consumer on the health benefits (and risks) of functional or energy foods, dietary supplements and ingredients
  • Understand how to properly market the science behind the product
  • Balance innovation, convenience and taste to drive the growth of the “healthy alternative” segment to include non-sports usage

For registration, discount rates and complimentary press passes, call Elizabeth Hutchison at 312-780-0700 ext. 179 and visit www.acius.net.

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Antioxidant Network May Help Protect Skin from Sun Damage

BACKGROUND: Topical sunscreens provide a barrier that reduces the amount of harmful ultraviolet rays in sunlight from reaching the skin. Some clinical studies have found that antioxidant supplements, such as beta-carotene, enhance antioxidant levels in the skin and resistance to sunburn. Multiple antioxidants -- the so-called "antioxidant network" -- may provide still greater benefits.

RESEARCH: In an experiment, researchers supplemented human skin cells with various combinations of antioxidants, including vitamin E, vitamin C, beta- carotene, lycopene, and carnosic acid (an extract of the herb rosemary).

Treated and untreated human cells were then exposed to ultraviolet A rays. The researchers measured levels of metalloproteinase 1 mRNA and heme- oxygenase 1, both markers of skin damage from ultraviolet rays.

RESULTS: Combinations of antioxidants were more effective than individual compounds in reducing metalloproteinase 1 mRNA levels after exposure to ultraviolet rays. Lycopene and beta-carotene by themselves were not protective, and they even increased metalloproteinase 1 mRNA levels. However, a combination of these carotenoids and vitamin E completely protected against this type of ultraviolet damage. A combination of vitamins E and C and carnosic acid was also protective. However, none of the antioxidants protected against heme-oxygenase 1 damage.

IMPLICATIONS: This study suggests that combinations of antioxidants -- the antioxidant network -- were effective in minimizing an important marker of ultraviolet damage to skin. Consumption of such antioxidants may help skin better withstand ultraviolet rays. The researchers wrote, "In the future, combinations of natural compounds may be envisaged for effective photoprotection."

Offord EA, Gautier JC, Avanti O, et al., "Photoprotective potential of lycopene, beta-carotene, vitamin E, vitamin C, and carnosic acid in UVA- irradiated human skin fibroblasts." Free Radical Biology & Medicine, 2002; 32:1293-1303.

For the original abstract, visit: http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&li st_uids=12057767&dopt=Abstract

Vitamin E in Supplements, Food May Protect Against Age-Related Cognitive Decline

BACKGROUND: Considerable research indicates that free radical (oxidative) damage in the brain may increase the risk of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. A variety of studies and experiments suggest that antioxidant supplements and an antioxidant- rich diet may reduce the risk of developing these diseases or slow their progression.

RESEARCH: Researchers at a major Chicago medical center tracked the health of 2,889 people, ages 65 to 102, for an average of three years. The subjects were given four standard tests to assess their cognitive function, including memory. They also completed a detailed questionnaire about their diets and the supplements they took.

RESULTS: People who consumed the greatest amount of vitamin E, from supplements and foods, had a 36 percent reduction in the rate of cognitive decline, compared with people who consumed the least amount of vitamin E.

Those who consumed the largest amount of vitamin E from food alone had a 32 percent reduction in the rate of cognitive decline, compared with those who obtained the least amount of vitamin E from food. People consuming the most vitamin E (from supplements and food) had the mental function of people eight to nine years younger than those who consumed little vitamin E.

IMPLICATIONS: This study suggests that vitamin E may play a significant role in slowing the age-related decline in mental function, including memory. According to the researchers, "Vitamin E intake, from foods or supplements, is associated with less cognitive decline with age." The researchers further suggested that increasing vitamin E intake to at least the recommended levels could have important public health implications.

Morris MC, Evans DA, Bienias JL, et al., "Vitamin E and cognitive decline in older persons." Archives of Neurology, 2002;59:1125-1132.

For the original abstract, visit: http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12117360&dopt=Abstract

Diet rich in soy protein lowers estrogens associated with breast cancer

Consuming tofu and other soy-based foods significantly lowers levels of a class of estrogens normally associated with breast cancer risk in postmenopausal women, according to a new study published in the September issue of the American Association for Cancer Research (AACR) journal, Cancer Epidemiology, Biomarkers & Prevention.

The study found a link between soy-rich diets consumed by Asian women in Singapore and reduced levels of an estrogen called estrone, the predominant form of estrogen in women following menopause. High estrogen levels have been shown to increase the risk for breast cancer among postmenopausal women.

Specifically, the study found that estrone levels were about 15 percent lower among women who consumed the highest amounts of soy protein. No other easily modifiable lifestyle factors analyzed by the scientists yielded such a dramatic hormone reduction.

"Results from this study support the hypothesis that high soy intake may reduce the risk of breast cancer by lowering endogenous estrogen levels, particularly estrone," said Anna H. Wu, the study's lead investigator and professor of preventive medicine at Keck School of Medicine of the University of Southern California, Los Angeles, Calif.

Also participating in the study, titled "Soy Intake and Other Lifestyle Determinants of Serum Estrogen Levels among Postmenopausal Chinese Women in Singapore," were Mimi C. Yu and Frank Z. Stanczyk, both at USC; and Adeline Seow and Hin-Peng Lee, with the Department of Community, Occupational and Family Medicine at the National University of Singapore.

Historically, breast cancer rates among Asians in Japan and China have been significantly lower than their female counterparts in the West. At one time, low-risk Asian women had one-sixth the breast cancer rate compared to high-risk whites in the United States and other parts of the western world. Reasons for this difference have remained largely unknown. However, Asians are clearly as "genetically susceptible," since Asian-American women have roughly the same breast cancer incidence as their white American neighbors.

Moreover, from the 1970s to the 1990s, breast cancer incidence more than doubled in Singapore and Japan. While earlier age at menarche, increasing numbers of women without children and delay in childbearing may offer a partial explanation, changes in other lifestyle practices are likely to play a role.

"Aside from answering some basic questions about soy consumption and breast cancer, this study may provide some insight into the underlying increase in breast cancer in Asia," said Dr. Stanczyk, a co-investigator and professor of research in obstetrics/gynecology at the Keck School of Medicine at USC.

Study participants included 144 healthy postmenopausal Chinese women in Singapore currently enrolled in a population-based prospective investigation of diet and cancer risk. Information on diet and other lifestyle factors was obtained from a structured questionnaire administered through direct interviews.

Each of the 144 postmenopausal women, ranging in age from 50-74 years, was asked to estimate her usual eating frequencies and portion sizes for 165 food and beverage items consumed during a year. The questionnaire also requested information on demographics, lifetime use of tobacco, menstrual and reproductive history, medical history, and family history of cancer.

The Chinese population in Singapore (and elsewhere in Asia) is particularly suited for studies on the effects of soy-based foods because this food has been a staple in the traditional Asian diet. Six kinds of soy products (plain tofu, taupok, taukwa, foopei, foojook and tofu far) and soybean drink were included in the questionnaire.

In addition, as part of a Singapore Food Composition Database, levels of daidzein, genistein and glycitein were measured in the main types of soy foods consumed in Singapore, allowing the researchers to calculate intake of total isoflavones among individual subjects. Isoflavones, the main constituent of soybeans, are believed to be responsible for anti-cancer effects observed in an accumulating number of human and animal studies.

"However, the effect of soy on the breast is controversial," said Dr. Wu. "There are some in vitro studies of breast cancer cells – animal studies, as well as short-term soy intervention studies in women – suggesting that soy isoflavines may have stimulatory effects." Added Dr. Mimi Yu, principal investigator of the Singapore Chinese Heaslth Study and a professor of preventive medicine at the Keck School of Medicine at USC: "Though our study is suggestive, more work needs to be done before any specific dietary recommendations can be made about consuming soy proteins to protect against breast cancer."

Blood sample analyses not only showed lower estrone levels among those consuming the highest quantities of soy protein, they also showed similar patterns when correlated to consumption of isoflavonoids. However, estrone levels did not decline in a linear manner with increasing soy intake; an apparent reduction was only seen among those in the top 25 percent of soy protein consumers.

The study also showed that hormone levels remained unaffected by other dietary and lifestyle choices. These included consumption of alcohol, coffee, tea, fat, fiber and various micronutrients, including vitamins A, C and E, along with calcium and carotenoids. Physical activity also did not significantly influence serum hormone levels. Among the study's other findings was an association between increased estrogen levels and women with a high body mass index (BMI), a measure of weight that accounts for height.

"There is a suggestion that weight change (particularly weight increase) has a profound influence on breast cancer rates in Asian-American women," said Hin-Peng Lee, co-principal investigator in the Singapore Chinese Health Study. "The same may now be happening to their relatives on the Asian side of the Pacific." The study also may open new avenues for basic research to determine how soy proteins work to reduce estrone levels on the molecular level. The scientific team hypothesized that isoflavones may inhibit certain enzymes responsible for estrogen production and metabolism. "Our findings of a reduction of estrone levels in association with soy intake may represent a reduction in the production and/or an increase in the elimination of estrone," said Dr. Stanczyk. "Future studies may offer new insights into this mechanism."

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Founded in 1907, the American Association for Cancer Research (AACR) is a professional society of more than 19,000 laboratory and clinical scientists engaged in cancer research in the United States, Canada, and more than 60 other countries. AACR's mission is to accelerate the prevention and cure of cancer through research, education, communication and advocacy. Its scholarly activities include the publication of five journals (Cancer Research, Journal of Clinical Oncology, Molecular Cancer Research; Cancer Epidemiology, Biomarkers & Prevention; and Molecular Cancer Therapeutics). AACR's annual meeting has more than 15,000 participants and features presentations of new and significant discoveries in the cancer field. AACR's 10 specialty meetings cover all of the important areas of basic, translational and clinical cancer research.

Jon Weiner
USC Health Sciences
323-442-2830, [email protected]

Anna H. Wu
323-865-0484, [email protected]

High Vitamin E Intake May Protect Against Alzheimer's Disease

BACKGROUND: Alzheimer's disease is the most common type of age-related dementia. It is characterized by the accumulation of a particular type of protein around brain cells that interfere with their activity. Some evidence indicates that free radicals promote the formation of this protein (beta-amyloid) and that vitamin E might protect against its formation. Two teams of researchers presented study results supporting these ideas at the recent Eighth International Conference on Alzheimer's Disease, held in Stockholm, Sweden. Preliminary results from the meeting abstracts are reported.

Study 1: Researchers from Johns Hopkins University, Baltimore, and other institutions analyzed dietary and health data from the Baltimore Longitudinal Study of Aging. They focused on 579 participants 60 years of age or older. During a nine-year period, 10 percent of the subjects developed Alzheimer's disease. People consuming the most vitamin E from supplements or food were 62 percent less likely to develop Alzheimer's disease, compared with those who consumed the least.

Study 2: Researchers from Case Western Reserve University, Cleveland, analyzed the diets that 74 patients with Alzheimer's disease had consumed when they were still in middle age, as recalled by a surrogate subject. These diets were then compared to those of 253 healthy subjects. Two dietary patterns emerged: one high in antioxidants and low in dietary fats, and the other low in antioxidants and high in dietary fats. People eating the high-antioxidant, low-fat diet were 55 percent less likely to develop Alzheimer's disease. The high-antioxidant, low-fat diet was especially protective for people with the ApoE e4 gene, considered a major genetic risk factor for Alzheimer's disease.

IMPLICATIONS: These studies, like the ones referred to above, provide support for a protective effect of vitamin E and antioxidants in reducing the risk of Alzheimer's disease or slowing its progression.

Corrada MM, Breitner JC, Hallfrisch J, et al., "Reduced risk of Alzheimer's disease with antioxidant vitamin intake: the Baltimore longitudinal study of aging." Abstract #1021. Petot GJ, Debanne SM, Traore F, et al., "Dietary patterns during mid-adult life and risk for Alzheimer's disease." Abstract #1124. Both presented at the Eighth International Conference on Alzheimer's Disease, Stockholm, Sweden, July 20-25, 2002.

For the original abstracts, visit: http://www.alz.org/internationalconference/abstracts.htm

Researchers Report that the Herb Hawthorn May Benefit Patients with

BACKGROUND: Hawthorn (Crataegus species) has been used medicinally in Europe for many centuries and for more than 100 years specifically in the treatment of heart disease. The herb is rich in a variety of antioxidants, particularly flavonoids and oligomeric proanthocyanidins.

RESEARCH: Researchers reviewed the history, chemistry, and clinical trials of hawthorn, focusing on its use in heart failure (moderately severe New York Heart Association stage II heart failure). The researchers cited 54 studies on hawthorn, some of which showed it to improve heart function and reduce blood pressure, arrhythmias, and blood fats.

RESULTS: The researchers described 10 clinical studies, most double-blind and placebo-controlled, showing that hawthorn could decrease heart rate, improve exercise tolerance, reduce systolic blood pressure, and lower blood fats. No significant side effects were reported in these trials. However, dosages of some drugs may have to be modified when taking hawthorn.

IMPLICATIONS: Hawthorn has been shown to improve heart failure and other types of heart disease. The researchers wrote, "Numerous clinical studies have demonstrated that hawthorn preparations are very effective in early stages of congestive heart failure, hypertension, angina, and minor arrhythmia."

Chang Q, Zuo Z, Harrison F, et al., "Hawthorn." Journal of Clinical Pharmacology, 2002;42:605-612.

For the original abstract, visit: http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12043949&dopt=Abstract"

International Conference on Dietary Supplements-Indian and Global Perspectives Friday 27 th Sept. 2002

Organized by :
INDIAN HEALTH FOODS AND DIETARY SUPPLEMENTS ASSOCIATION (INHADSA)

Co-Sponsored and Venue: Scitech
At: SCITECH CENTRE,
7 Prabhat Nagar, Jogeshwari(W)
Mumbai-400102 (India)

ABOUT INDIAN HEALTH FOODS AND DIETARY SUPPLEMENTS ASSOCIATION (INHADSA)

The Indian Health Foods and Dietary Supplements Association (INHADSA), founded in April 2002, keeping the consumer benefits in mind, represents the interests of manufacturers and suppliers of vitamin, mineral and botanical products including organic and health foods, natural ingredient cosmetics, sports nutrition products, herbs and other dietary supplements.

INHADSA is a national, non-profit trade association committed to providing consumers with safe, effective products made to quality standards. Further, the association will support a science-based environment for the responsible marketing of nutritional supplements and will ensure that consumers are provided with the accurate information they need to make informed choices. Our commitment includes compliance to applicable laws and regulations consistent with International guidelines and standards, but to seek to change or question those laws or regulations that are inconsistent with the best interest of the public.

INHADSA unites a diverse membership, from the smallest health food store to the largest natural product supplier. We champion consumers' freedom of choice in our marketplace. We strengthen and safeguard a free market economy. We build strong markets to fuel industry growth. We act together with uncompromising integrity, and we encourage all to reach ever-higher standards of quality. The Government of India is seeking Industry’s in put for the recently proposed draft on Health Foods and Dietary Supplement bill to develop an appropriate regulatory framework. In support of the Government’s intention, by providing an international forum, INHADSA attempts to bring together the recognized experts in this field for proper understanding and review of the dietary supplement product category.

ABOUT THE CONFERENCE:

INHADSA has been recently been set up by leading companies operating in India in the important area of Health Foods and Dietary Supplements.

The first Asia Conference on Dietary Supplements is being held at Bangkok on 24 –25 September , 2002 (Tuesday-Wednesday) and it is being addressed by a number of international experts . We are organizing a one-day conference in Mumbai almost immediately thereafter on Friday, September 27, 2002 so that it would be convenient for some of the speakers from the Bangkok conference to speak at our conference. The conference is going to be held at SciTech Center auditorium at Jogeshwari , Mumbai .

Like elsewhere in the world, Government of India is seeking to develop an approved regulatory frame-work for dietary supplements. Our conference will aim to improve understanding of dietary supplements, the market and the regulatory requirements. It will also aim to provide a springboard for future discussions, developments of the market place and provide an all-industry perspective to promote well-defines guidelines towards self-regulation. We expect a good participation from industry as well as regulators. The conference will be very timely, as the Government has already proposed a draft regulation on Health Food and Dietary Supplements.

Natural Products Expo East Seminar: Attention Natural Product Retailers

DON’T MISS THIS IMPORTANT SEMINAR AT EXPO EAST:

HRT – WHAT NOW?

Saturday, October 5th, 2-3 p.m.
Washington D.C. Convention Center – Room 14
(Refreshments will be served)

With an introduction by Mark Blumenthal of the American Botanical Council, seminar speakers include: Lisa Nachtigall, M.D.; Sonya Lee, M.D.; and Don Brown, N.D. Retailers will hear how these experts work with alternative approaches, the latest research and how to answer customers’ questions about menopause.

Before the seminar, retailers can stop by the Novogen booth #601 to pick up their seminar drawing card, and hand it in when entering the seminar for an automatic entry for the drawing at the end of the presentation for a FREE floor display of Promensil and Rimostil.

Editorial: Weight Loss Advertising: A Perspective

By Len Monheit

Earlier this week, the US Federal Trade Commission issued its report and press releases regarding weight loss advertising and trends it has observed over recent years. With well over 50% of weight loss advertising determined to be false, misleading and unsupported by science and evidence, the recap and presentation did not bolster the sector at all.

Within the report and evident in the communications, was the beginning of a consumer education program and a call for more responsibility on the part of marketers of weight loss products.

The message of responsibility was also intended for publishers and the media, in fact, the text of the report states, “In the absence of laws and regulations to protect the public against dangerous or misleading products, a priority exists for the media to willingly ascribe to the highest advertising standards, i.e. those that reject the creation and acceptance of advertisements that contain false or misleading weight loss claims.”

Weight Loss Advertising- an analysis of current trends”, FTC, September 17, 2002.

This extension of responsibility may appear obvious, but perhaps it is the tip of the iceberg, as higher responsibility and accountability is called for throughout the industry. Several publications and tradeshow organizers screen materials before printing or display at events, and I think we can expect this trend to increase. Will outsourced marketing and communications professionals (writers, advertising and PR agencies etc.) also be more accountable? If so, then industry familiarity, issue familiarity, and an excellent performance record become even more critical in selecting these services.

Taking responsibility and accountability in a different direction--a supplier certificate and a good historical relationship used to be enough to establish credibility, legitimacy, and proof of product identity and efficacy. This perception has changed in recent years, and as consumers and agencies become more aware of labeling discrepancies and product contamination, pressure is being applied for all suppliers along the chain to be more responsible and accountable for the products and services they offer. In-house or third party testing is more common, the role of the distributor or agent is changing, as is the level of responsibility expected of these firms. We can certainly expect to see a more transparent supply chain and marketplace as manufacturers and ultimately consumers and regulators will want to see a chain under complete management, with accountable and responsible firms at every juncture.

Another issue raised in the FTC communications this week was the need for consumer education about obvious fallacies in advertising. This underscores again the need for an industry consumer education strategy for the industry as a whole, if only to try to maintain a balanced perspective.

Over the past several months, I have heard many times over that the key to success for the future of the industry is to reach an expanded consumer base with our products and message, and this task is becoming more difficult.

And the many are judged by the behavior of the few.

And credibility is fragile.

American Botanical Council Releases Scientific Information on Black Cohosh For Menopause

Timely Information Helps Women and Healthcare Professionals Assess Natural Treatment Options for Menopause Symptoms

AUSTIN, Texas, Sept. 20 -- The American Botanical Council, an independent nonprofit organization, is making available to the public, a monograph or scientific review of the health benefits of a leading herb used by many women to treat symptoms of menopause.

The herb, black cohosh, known by its Latin names Actaea racemosa and Cimicifuga racemosa, is a native American herb with a long history of use. Black cohosh was used by Native American Indians for "female problems," and was a major ingredient in Lydia Pinkham's famous women's tonic, sold for more than 50 years in the 19th century.

A special formulation of black cohosh was developed in the early 1940s in Germany as a natural agent for treating menstrual and menopausal symptoms. This herbal preparation has been used in the majority of the clinical trials that have been conducted. These studies support its safety and efficacy for treating the physical and emotional symptoms of menopause, including hot flashes, night sweats, mood swings, irritability and occasional sleeplessness associated with menopause.

The product studied in most of the trials has been used in Germany since the mid 1950s and is currently marketed in the U.S. under the name RemiFemin(R) Menopause. The German government's Commission E, a special committee of physicians, pharmacists and other scientific experts to evaluate and approve herbs, has approved black cohosh as a nonprescription medicine for treatment of various symptoms associated with menopause.

"As researchers, healthcare providers and menopausal women consider the implications of the recent reports by the National Institutes of Health and the National Cancer Institute that question the safety and long-term health benefits of hormone replacement therapy, the ABC monograph provides important information on the clinical data supporting black cohosh as a natural treatment option for menopause symptoms," said Mark Blumenthal, founder and executive director of ABC.

"Now, more than ever, it is critically important for menopausal women to discuss treatment options -- including reliable alternatives -- with their healthcare providers," said Mary Hardy, MD, director of the Integrative Medicine Medical Group at Cedars-Sinai Medical Center in Los Angeles. "The ABC monograph provides an excellent overview for clinicians as well as patients who want to better understand the science behind black cohosh," she added.

Consumers and health professionals can find more information about the clinically documented benefits of black cohosh by logging onto ABC's website at http://www.herbalgram.org . Included is an extensively referenced profile of black cohosh for health professionals containing a discussion of clinical data with a table summarizing clinical trials. For consumers the site has a one-page Patient Information Sheet that is based on information condensed from the larger scientific monograph. Both the scientific information and the patient information sheet are part of a new reference book, The ABC Clinical Guide to Herbs, being published by ABC early next year. The book is accredited for continuing education for physicians, pharmacists, nurses, dietitians, and other healthcare professionals.

Dr. Hardy added that she does not recommend that women on HRT discontinue their hormone pills without consulting with their physicians. She also discussed the importance of choosing herbs based on individual symptoms and needs. "There is an increasing amount of evidence supporting the use of black cohosh as well as soy, red clover and some other dietary supplements in treating menopausal symptoms. Women should discuss with their doctors or other healthcare professionals who are knowledgeable about herbals which options may be appropriate for them," she noted.

Dr. Hardy added that part of the problem is that many physicians have not been exposed to the scientific research on clinically researched alternatives. "We as health professionals have a responsibility to evaluate the science on herbal dietary supplements in order to guide our patients appropriately. Reliable resources like the ABC Clinical Guide are an excellent way to review the existing research on various herbs, " she said.

The American Botanical Council is the nation's leading nonprofit organization addressing research and educational issues regarding herbs and medicinal plants. The 13-year-old organization occupies a 2.5-acre site in Austin, Texas where it publishes HerbalGram, a peer-reviewed journal on herbal medicine, and will publish a forthcoming book and continuing education course for healthcare professionals, The ABC Clinical Guide to Herbs, containing an extensive monograph on the safety and efficacy of black cohosh. Information contact: ABC at P.O. Box 144345, Austin, TX 78714-4345, ph: 800-373-7105. Website: http://www.herbalgram.org .