Kyowa Hakko USA Inc., the wholly owned subsidiary of Kyowa Hakko Bio Co. Ltd., has announced it has completed GRAS (generally recognized as safe) self-affirmation for the valuable amino acid L-citrulline.

L-citrulline is an amino acid that plays an important role in nitric oxide (NO) metabolism and regulation. L-citrulline is converted to L-arginine in the body to support L-arginine and NO levels. Increased production of NO promotes vascular dilation which improves oxygen and blood circulation throughout the body. L-citrulline is also expected to relieve muscle fatigue through ammonia elimination. Antioxidant action and heart protection are also known.

“We are extremely proud to announce GRAS for our amino acid L-citrulline, and look forward to working with manufactures to incorporate it into foods and beverages,” said Dr. Toshikazu Kamiya, president and CEO of Kyowa Hakko USA.

L-citrulline is preservative-free, allergen-free, and contains no artificial flavors or colors. Manufactured in the U.S. using a proprietary fermentation process, L-citrulline is an ultra-pure amino acid that carries the Kyowa Quality logo, ensuring that this ingredient is backed by our commitment to the highest manufacturing standards.

L-citrulline will be marketed by Kyowa Hakko USA as a food ingredient in the United States for use at levels of 275 mg of L-citrulline/serving up to a maximum of 2,000 mg/day in various food products, such as beverages and beverages bases; grain products and pastas; and milk products.