WOKVEL® Extract found effective in comparative human study for joint health

Noblesville, IN – March 19, 2007 - Published results on the latest human study on WOKVEL Extract, the proprietary, all natural Boswellia serrata extract clinically researched for optimal joint health, found a sustained decrease in WOMAC score for WOKVEL Extract and valdecoxib, a non-steroidal anti-inflammatory drug (NSAID) over a seven month period.(1)

The subjects in the 6-month, randomized, prospective, comparative study were assessed using the WOMAC (Western Ontario and McMaster University Osteoarthritis Index) scale each month, and then assessed at 7 months after baseline, after a one month washout.

An overall decrease in WOMAC values, which marked an increase in joint health and function, were observed each month, through six months after baseline for both WOKVEL Extract and valdecoxib. After the one month washout, WOMAC scores of WOKVEL Extract group remained low, while scores for valdecoxib increased back to near-baseline values. The results indicate WOKVEL Extract offers a sustained joint health effect, which may be related to prior reports on the functional cellular processes important for inflammatory reactions by boswellic acids.(2)

According to the American College of Rheumatology, 70% of those over age 70 exhibit x-ray evidence of osteoarthritis, which affects more than 20 million Americans.(3)

The study, published in the February 2007 issue of the Indian Journal of Pharmacology, is the third published human study performed on WOKVEL Extract. A previous study published in the journal Phytomedicine in 2003 showed WOKVEL Extract efficacious for inflammatory issues associated with the knee.(4) A human pharmacokinetic study on WOKVEL Extract, published in Phytomedicine in 2004, detected 11-keto-beta-boswellic acid (KBA) to be the primary boswellic acid detected into the bloodstream. The dosage of WOKVEL Extract, determined in this study, is 333 mg three times daily.(5)

WOKVEL Extract, a synergistic, HPLC standardized Boswellia extract containing a proprietary fingerprint of all six beneficial beta-boswellic acids, supports joint health and flexibility through regulation of 5-lipoxygenase (5-LO) synthesis.(6) Mediation of 5-LO is shown to positively affect a number of inflammatory concerns, including those centered on joint, digestive, vascular, and cellular health.

WOKVEL Extract has been well tolerated in clinical studies, and similar ADR’s to placebo have been reported. A product of vertical integration, WOKVEL Extract is custom manufactured in Verdure Sciences' hands-free, ISO 9001-2000 and HACCP facility. WOKVEL Extract is Prop-65 compliant, pesticide-free, and Kosher- and Halal-certified. More information can be found at www.wokvel.com.

About Verdure Sciences™:

Verdure Sciences strives to offer the most innovative bionutritionals through the integration of proprietary offerings, expertise, and consummate resources.

With the main focus on research and production capabilities, an extensive pipeline of clinically studied products is geared to the needs of general populations and subpopulations with special health concerns.

Selected References:
1. Open, randomized, controlled clinical trial of Boswellia serrata extract as compared to valdecoxib in osteoarthritis of knee. Indian Journal of Pharmacology. 2007; 39(1) 27-29
2. Boswellic acids: biological actions and molecular targets. Curr Med Chem. 2006;13(28):3359-69.
3. http://www.rheumatology.org/public/factsheets/oa_new.asp#2
4. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial. Phytomedicine. 2003 Jan;10(1):3-7.
5. Pharmacokinetic study of 11-Keto beta-Boswellic acid. Phytomedicine. 2004 Feb;11(2-3):255-60.
6. Boswellic acids in chronic inflammatory diseases. Planta Med. 2006 Oct;72(12):1100-16. Review.

Blake Ebersole, [email protected]

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