WAYNE, N.J., May 6, 2002 – Nutratech, Inc. – a research-based nutraceutical ingredient manufacturer –
has announced that the U.S. Patent and Trademark Office has issued three more patents to Zhishin LLC for
Advantra Z®, the only patented Citrus aurantium extract for weight loss and physical performance on the
market today. While Zhishin LLC holds the patents, Nutratech is the exclusive worldwide licensee for
In addition to granting U.S. Patent No: 6,224,873 for stimulating thermogenesis and reducing weight, the
U.S. Patent and Trademark Office has recently issued U.S. Patent Nos: 6,316,499, 6,340,481 and 6,340,482
for increasing the ratio of lean muscle to total body mass, improving athletic performance and suppressing
appetite, respectively. Other U.S. and international patents are pending.
Unlike generic counterparts on the market, most of the research on Citrus aurantium has been conducted
using Advantra Z®, which utilizes optimal harvesting techniques and a proprietary extraction process to
produce a truly unique synergistic amine composition. This complete composition of five synergistic
adrenergic amines: synephrine, n-methyltyramine, hordenine, octopamine and tyramine is responsible for
delivering the applications protected by the aforementioned series of patents and the positive results found
in the research.
By purchasing Advantra Z®, customers can tout the applications supported in the patents, subject to their
attorney’s comments and/or approval, on their label and marketing support material. This gives
Nutratech’s customers a one-up advantage over their competition who may be purchasing the generic
Citrus aurantium and, therefore, cannot legally make these claims. As the exclusive worldwide licensee for
Advantra Z®, Nutratech is vigorously pursuing a licensing program with companies who want to use the
claims supported by these patents in order to protect its customer’s competitive advantage in the
In addition to Advantra Z®’s extensive patent protection, it also offers an excellent efficacy profile. In the
wake of controversy surrounding the popular herb, ma huang (ephedra), Advantra Z® has emerged as the
ideal thermogenic alternative, working as effectively as the former when used properly without the
potentially negative central nervous system and cardiovascular side effects.
Nutratech, Inc. with headquarters in Wayne, NJ provides innovative, proprietary and patented nutraceutical
ingredients with efficacy claims that are supported by sound scientific research.