Association of Midlife Dietary Intake of Antioxidants to Late-life Dementia Examined

According to a study published in the American Journal of Epidemiology (Am J Epidemiol 2004; 159:959-967 'Midlife Dietary Intake of Antioxidants and Risk of Late-Life Incident Dementia - The Honolulu-Asia Aging Study'.), the authors examined the association of midlife dietary intake of antioxidants to late-life dementia and its subtypes.

Data were obtained from the Honolulu-Asia Aging Study, which studied 2.459 Japanese-American men aged 45–68 years in 1965–1968, when a 24-hour dietary recall was administered. The subjects were dementia-free in 1991–1993 and were examined up to two times for dementia between 1991 and 1999. The sample included 235 incident cases of dementia (102 cases of Alzheimer’s disease, 38 cases of Alzheimer’s disease with contributing cerebrovascular disease, and 44 cases of vascular dementia).

Relative risks by quartile of intake were calculated with age as the time scale, after adjustment for sociodemographic and lifestyle factors, cardiovascular risk factors, other dietary constituents, and apolipoprotein E e4. Intakes of beta-carotene, flavonoids, and vitamins E and C were not associated with the risk of dementia or its subtypes. This analysis suggests that midlife dietary intake of antioxidants does not modify the risk of late-life dementia or its most prevalent subtypes.

Danielle Laurin1, Kamal H. Masaki2, Daniel J. Foley1, Lon R. White2 and Lenore J. Launer1
1 Neuroepidemiology Section, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD.
2 Pacific Health Research Institute, Honolulu, HI.

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