DuPont's HOWARU Restore relieves antiobiotic side effects

Research on reformulated probiotic will be discussed during “Probiotics: New Clinical Data and the Path to Better Digestive Health” at SupplySide West.

DuPont Nutrition & Health announced the results of a new clinical study on a reformulated version of HOWARU® Restore—part of the DuPont™ Danisco® range of premium probiotics—indicating a reduction in the risk of antibiotic associated diarrhea in patients undergoing antibiotic therapy.

Already a worldwide success
HOWARU Restore, a unique probiotic formulation incorporated into dietary supplements already sold in 10 countries with great success, has a well-documented ability to replenish intestinal microbiota during gastrointestinal stresses. Its effectiveness was recently recognized via the results of a 2012 survey of 7,000 Australian consumers in which Faulding® Probiotic—based on HOWARU Restore—was selected as “Product of the Year” in the Adult Health category. 

New optimized formulation with proven benefits
DuPont Nutrition & Health has now introduced an optimized formulation of HOWARU Restore comprised of four key strains from the DuPont Danisco strain portfolio: Lactobacillus acidophilus NCFM®, Bifidobacterium lactis Bl-04™, Bifidobacterium lactis Bi-07™, and Lactobacillus paracasei Lpc-37™.

The new formula was tested on 503 patients undergoing antibiotic therapy in a triple-blind, randomized, placebo-controlled study. The HOWARU Restore formulation demonstrated effectiveness in reducing the impact of antibiotic associated diarrhea in patients under antibiotic therapy with:

  • A significant reduction of the number of episodes of antibiotic associated diarrhea.
  • A significant reduction in the duration of diarrhea and the number of liquid stools.
  • A significant reduction of diarrhea-associated symptoms such as fever, bloating and abdominal pain.

“While antibiotics are highly valuable, their use also can have detrimental effects on gut microflora, which can result in bouts of diarrhea and intestinal discomfort,” said Gregory Leyer, business development director of Consumer Healthcare. “A probiotic supplement that combats these unwanted side effects would provide welcome relief to consumers.”

Learn more at SupplySide West 2012
New HOWARU Restore clinical results will be discussed when Leyer presents “Probiotics: New Clinical Data and the Path to Better Digestive Health” during the SupplySide West show in Las Vegas. The presentation, which also will include recent information on global digestive health market trends, takes place on Wednesday, Nov. 7, at 10 a.m. (PST). Interested show attendees also are invited to visit DuPont at booth number 25019.

DuPont Danisco is the brand for a range of products that help provide enhanced bioprotection, an improved nutritional profile, and better taste and texture with greater cost efficiency and lower environmental impact, meeting the needs of manufacturers of food and beverages, dietary supplements and pet food.  Through the work of the global network of food scientists and technologists in DuPont, the Danisco® range is supported by a uniquely broad spectrum of know-how across applications and processing.

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