Evidence-Based Products

Study claim: Bioavailability doesn?t differ between lutein ester and free lutein.

Published: Chung HY, et al. Lutein bioavailability is higher from lutein-enriched eggs than from supplements and spinach in men. J Nutr 2004 Aug; 134(8):1887-93.

Abstract: Lutein may be protective against diseases such as age-related macular degeneration. In an intervention study with a crossover design, 10 healthy men began with a two-week washout period during which they consumed a low-carotenoid diet. The men were administered one of four lutein doses (lutein supplement, lutein ester supplement, spinach and lutein-enriched egg) for nine days. All lutein doses provided 6mg lutein except for the lutein ester dose, which provided 5.5mg lutein equivalents. Serum samples were collected from fasting subjects before the washout period, then on days one (baseline), two, three and 10, and analysed for changes in lutein concentration. Triacylglycerol-rich lipoproteins were separated from postprandial blood samples after the first lutein dose and analysed for lutein concentration.

Results showed the baseline and dose-adjusted lutein response in serum was significantly higher after egg consumption than after lutein, lutein ester and spinach consumption on day 10. The eggs were from chickens fed a lutein-enriched diet, containing five times the amount of lutein of conventional eggs. There was no difference between supplements and spinach.

Further analysis showed soft gel supplements containing lutein from Cognis? Xangold natural lutein esters and free lutein from Vitamin Power lutein capsules exhibited the same bioavailability. The similar results between free lutein and lutein esters suggest ester hydrolysis is not a limiting step for the absorption of lutein from lutein diesters. There was no significant difference in TRL response. This finding may have implications for dietary recommendations that may decrease the risk of certain diseases.

Potential applications: Xangold natural lutein esters are available in two forms suitable for foods and supplements: 15 per cent oil for soft gel capsules and oil-based food products, and 10 per cent micro-encapsulated beadlets for tablets or dry foods. Both forms are available in IP-certified, non-GM grades.

More info: Cognis
[email protected]

Study claim: Aquamin F is more bioavailable than calcium carbonate. Aquamin F also resulted in a more prolonged decline in serum parathyroid hormone (PTH) levels, which reflect serum calcium levels.

Published: Zenk, John L; Leikam, Sandra A; Kuskowski, Michael A. A single-dose pharmacokinetic and pharmacodynamic comparison of two calcium supplements in premenopausal women. FASEB J 2004; 18(5):A920 Abstract No. 608.4.

Abstract: In this randomised, double-blind, placebo-controlled crossover trial, 12 healthy women (age 20-40 years) were given a single oral dose of Aquamin F and calcium carbonate, delivering 720mg elemental calcium. Blood was obtained at 13 time points over the 12-hour study period for the determination of ionised and total calcium, magnesium, phosphorus and PTH. There was no difference between the treatments in regard to ionised and total calcium levels. Aquamin F revealed a significantly greater urinary clearance of calcium than the calcium carbonate compared to placebo. There was no difference in the PTH area-over-the-curve measurements between the Aquamin F and calcium carbonate treatments, but the Aquamin F demonstrated a more prolonged suppression of PTH levels at 120 and 240 minutes. There were no significant differences in any of the other measured variables and no serious adverse events.

Potential applications: Aquamin F is a natural calcium source produced from mineralised seaweed (Lithothamnion spp.) off Ireland. Aquamin F can be used in supplements and foods like cereals, pasta, noodles, biscuits, baked goods, processed meats, ice cream and confectionery. It is soluble in weak acids, insoluble in water.

More info: Marigot Ireland
+353 21 437 8727

Study Claim: A review of more than 60 human, animal and cellular studies confirms that chromium picolinate is safe for use as a nutrient supplement in food.

Published: Berner TO, et al. Determining the safety of chromium tripicolinate for addition to foods as a nutrient supplement. Food Chem Toxicol 2004 Jun; 42(6):1029-42.

Abstract: Toxicologists and food science experts at the ENVIRON Health Sciences Institute cited a significant body of evidence conducted by scientists at leading academic institutions, as well as the USDA and the National Institutes of Health?s National Toxicology Program. Trivalent chromium is an essential element required for normal carbohydrate, lipid and protein metabolism. One particular form of trivalent chromium, chromium tripicolinate (Chromax), a stable complex of trivalent chromium and picolinic acid, was determined to be safe for use as a nutrient supplement in foods.

A safety assessment of a nutrient supplement for use in food requires an evaluation of the safety of the product (Chromax), as well as an evaluation of the safety of the intended dietary ingredient (chromium tripicolinate). In this assessment, the production process, final product specifications and product analysis results for Chromax were evaluated. Then, the Estimated Daily Intakes (EDIs) of trivalent chromium and picolinic acid from the proposed use of Chromax were calculated using data from the USDA?s Continuing Survey of Food Intakes by Individuals. The EDI for trivalent chromium was compared to the Acceptable Daily Intake (ADI) for this compound derived from animal studies, corroborated with human data, while the EDI for picolinic acid was compared to existing in vivo exposure to this compound that occurs naturally in the body. As long as the EDI of trivalent chromium is less than the ADI for this compound and the EDI of picolinic acid is less than its estimated in vivo exposure, Chromax can be considered safe for its intended use.

Potential applications: Chromax is generally recognised as safe for use in nutritional bars and beverages as a nutrient supplement at a maximum use level of 2.4mg Chromax per product serving.

More info: Nutrition 21
+1 914 701 4500

Study Claim: NutriCran-GI is significantly more potent in inhibiting Helicobacter pylori bacteria in vitro when compared to single antimicrobial compounds. These data support the likelihood that NutriCran-GI may be more effective in managing H. pylori infections in humans.

Published: Vattem DA, et al. Cranberry synergies for dietary management of Helicobacter pylori infections. Process Biochemistry 2005; In press.

Abstract: Cranberry?s benefits are associated with phenolic phytochemicals in the juice, which may inhibit cancer and cardiovascular diseases. Helicobacter pylori is a human pathogen linked to peptic ulcer and cardiovascular diseases. Control of this pathogen using antibiotics has limitations due to the development of resistance and low compliance. A suite of antimicrobials compared to a single compound could be potentially more effective in managing H. pylori. The effects of cranberry, blueberry and grape seed extracts — both individually and in three combined formulations — on inhibiting H. pylori have been investigated. The ability of blueberry, grape seed and oregano extracts to enhance the antioxidant and anti-H. pylori activity of cranberry powder in a mixture was also investigated.

The anti-H. pylori activity of the cranberry fruit extracts and their synergies correlated with antioxidant activity and the presence of biphenyls as well as polyphenolic phytochemicals. The anti-H. pylori activity of cranberry juice extract was significantly improved by its blending with blueberry, grape seed and oregano extracts. The lower efficacy of purified phenolics in inhibiting H. pylori compared with fruit powder at similar dosage levels suggests a synergistic mode of functionality of these individual phenolics in a whole food background. Consumption of blends of fruit juices with other fruit as well as herb extracts could be an effective strategy in management of H. pylori infections as well as other oxidation-linked diseases.

Potential applications: NutriCran-GI is a blend of DBS?s cranberry powder, Polyphenolic?s MegaNatural Gold grape seed extract and Durham Research?s BluePhenolic wild blueberry powder. It is suitable for beverages, foods and supplements.

More info: Decas Botanical Synergies
+1 508 295 0147

To submit newly published research on your company?s ingredients, please email [email protected] for details.

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