Evidence-based Products

PUBLISHED: Berman M, et al. Coenzyme Q10 in patients with end-stage heart failure awaiting cardiac transplantation: a randomized, placebo-controlled study. Clin Cardiol 2004 May; 27:295-9.

STUDY CLAIM: Ultrasome-CoQ10 (Emulsome) shows significant improvement in heart transplant candidates? conditions.

ABSTRACT: Thirty-two patients with end-stage heart failure awaiting heart transplantation were randomly allocated to receive either 60mg/day Ultrasome-CoQ10 (a special preparation to increase intestinal absorption) or placebo for three months. Assessments included anamnesis with an extended questionnaire, six-minute walk test, blood tests for atrial natriuretic factor (ANF) and tumour necrosis factor (TNF), and echocardiography. The study group showed significant improvement in the walk test and a decrease in dyspnea, New York Heart Association classification, nocturia and fatigue. However, no significant changes were noted after three months of treatment in echocardiography parameters, or ANF and TNF blood levels.

POTENTIAL APPLICATIONS: Emulsome, made by Israel-based Herbamed, is sold as a bulk powder for use in tablets, capsules, and functional foods and liquids.

MORE INFO: [email protected]

PUBLISHED: Lee EH, et al. Dietary lutein reduces ultraviolet radiation-induced inflammation and immunosuppression. J Invest Dermatol 2004 Feb; 122(2):510-7.

STUDY CLAIM: Dietary lutein may contribute to the defense against some of the deleterious effects of solar radiation.

ABSTRACT: Mice were fed diets containing 0%, 0.04% or 0.4% of FloraGLO Lutein for up to 35 days. Researchers examined four parameters: 1) amount of lutein found in the skin; 2) relative amounts of reactive oxygen species (ROS) in the skin following UV exposure (a measure of its antioxidative effect); 3) the degree of ear swelling caused by UV exposure (a potential measure of inflammation); and 4) the degree of suppression of the skin?s immune functionality induced by UV exposure. Animals fed the 0.4% lutein diet resulted in significant amounts of lutein in the skin in 14 days; those fed 0.04% showed significant amounts at 35 days. After 28 days of ingestion, experiments showed a significant dose-dependent reduction in ROS on the 0.4% dose. Twenty-four hours after exposure to a single 350mJ/cm2 dose of UV light, animals on the 0.4% dose showed significant reduction in swelling. Both doses resulted in significant reduction of immune suppression.

POTENTIAL APPLICATIONS: FloraGLO Lutein by Kemin Foods is sold in liquid and beadlet forms for use in foods and supplements.

MORE INFO: +1 515 248 4000

To submit newly published research on your company?s ingredients, please email [email protected] for details.

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