Evidence-Based Products

Functional Foods & Nutraceuticals' monthly digest of company research on scientifically validated ingredients published in peer-reviewed journals.

Albion™ Advanced Nutrition
STUDY CLAIM: Iron in Ferrochel had a bioavailability of 90.9 per cent compared with the 26.7 per cent iron absorbability of ferrous sulfate. Ferrochel is safe because the body regulates iron absorption according to hemoglobin changes.

PUBLISHED: Pineda O, Ashmead HD. Effectiveness of treatment of iron-deficiency anemia in infants and young children with ferrous bisglycinate chelate. Nutrition 2001;17:381-4.

ABSTRACT: Researchers studied 46 infants, ages 6­36 months old, with iron-deficiency anemia (hemoglobin < 11 g/dL). They divided the group into two and gave each subject a daily dose of 5mg/day per kg of body weight; one group received FeSO4 and the other ferrous bisglycinate chelate (Ferrochel). Hemoglobin increased in both groups. However, plasma ferritin increased significantly in the group that received Ferrochel. Researchers calculated apparent iron bioavailabilities at 26.7 per cent for FeSO4 and 90.9 percent for Ferrochel.

Regression analysis revealed that changes in hemoglobin similarly regulated absorption of both iron sources. Researchers concluded that Ferrochel is an effective treatment for infants with iron-deficiency anemia because of its high bioavailability and regulation.

POTENTIAL APPLICATIONS: Ferrochel has been introduced in a growing number of functional food and beverage products because of its ability to correct anemia, its organoleptic properties and its safety.

COMPANY INFO: Founded in 1956, Albion produces patented amino acid chelated minerals used for humans, animals and plants.
101 N. Main St.; Clearfield, Utah 84015;
Tel: + 1-800-453-2406; www.albionlabs.com

STUDY CLAIM: Fibersol-2 (maltodextrin) may help maintain healthy levels of serum cholesterol, blood triglycerides and postprandial blood glucose, and promote intestinal-tract health.

PUBLISHED: Flickinger E, et al. Glucose-based oligosaccharides exhibit different in vitro fermentation patterns and affect in vivo apparent nutrient digestibility and microbial populations in dogs. J Nutr 2000;130:1267-73.

ABSTRACT: Researchers compared in vitro fermentation characteristics of two novel oligosaccharides (OS)—glucosaccharides (GOS) and maltodextrinlike OS (MD), with fructo-oligosaccharides (FOS), gum arabic (GA), guar gum (GG) and guar hydrolysate (GH). Total short-chain fatty acid (SCFA) production (umol/g dry matter) as a result of MD fermentation was higher initially compared with GA (p < 0.01), but GA was more extensively fermented after 24 hours (p < 0.01). Total SCFA production for GOS was similar to that for FOS, GA, GG and GH.

In the second experiment, researchers fed ileal-cannulated dogs an internal formula control diet with six per cent GOS and MD. Study design was a 3 x 3 replicated Latin-square. Ileal digestibility of glucose was lower (p < 0.05) and carbohydrate digestibility also was numerically lower (p = .08) for both GOS and MD compared with the control. Total tract digestibility of carbohydrates and glucose was lower only for MD compared with the control. Total fecal weights were higher for both GOS and MD treatments. Fecal concentration of bifidobacteria was numerically increased by GOS and MD supplementation. Thus, GOS and MD are indigestible yet fermentable OS and may act as dietary fibre-like ingredients.

POTENTIAL APPLICATIONS: Fibersol-2 can be added to most foods and remains transparent, tasteless and odourless.

COMPANY INFO: Japan-based Matsutani has been a pioneer in the starch-processing industry since 1919.
951 Bunker Lane; Decatur, Illinois, 62526;
Tel: + 1-217-875-9819; www.matsutani.com

FloraGlo Lutein
STUDY CLAIM: Using eyes from human donors within 24 hours of death, researchers found FloraGLO proteins are involved in the uptake and metabolism of lutein in the macula.

PUBLISHED: Yemelyanov A, et al. Lignand-binding characterization of xanthophyll carotenoids to solubilized membrane proteins derived from human retina. Exp Eye Res 2001;72:381-92.

ABSTRACT: The macula of the human retina contains high concentrations of lutein and zeaxanthin, both xanthophyll carotenoids that appear to protect against age-related macular degeneration, which is the leading cause of blindness in the elderly. Specific xanthophyll-binding proteins may mediate the uptake and stabilisation of these carotenoids. In order to purify and characterise such a binding protein, researchers prepared a carotenoid-rich membrane fraction derived from human macula or peripheral retina. The most highly purified preparations contained two major protein bands at 25 and 55 kDa that consistently coeluted with endogenous lutein and zeaxanthin. The visible absorbance spectrum of the binding protein preparation closely matched the spectral absorbance of the human macula pigment and was bathochromically shifted about 10 nm from the spectrum of lutein and zeaxanthin dissolved in organic solvents.

Binding of exogenously added lutein and zeaxanthin is saturable and specific with an apparent Kd of approximately 1 uM. Canthaxanthin and beta-carotene exhibit no significant binding activity to solubilized retinal membrane proteins such as albumin, tubulin or lactoglobulin; serum lipoproteins possess only weak nonspecific binding affinity for carotenoids when assayed under the same stringent binding conditions.

This study provides the first direct evidence that specific xanthophyll-binding proteins exist in the retina and macula. The possible roles of xanthophyll-binding proteins in normal macular function and in the pathogenesis of age-related macular degeneration warrant more research.

POTENTIAL APPLICATIONS: FloraGLO is available in liquid and beadlet form as a defence against age-related macular degeneration.

COMPANY INFO: Founded in 1961, Kemin Foods manufactures natural antioxidant ingredients for the food, dietary supplements and personal care industries.
2100 Maury St., Box 70; Des Moines, Iowa
50301-0070; Tel: + 1-515-266-2111, + 1-800-777-8307; www.kemin.com.

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