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High Molecular Weight HA Shown to be Taken Up in Connective Tissues

An animal study on Fenchem’s HyaMax® Sodium Hyaluronate indicates that after oral administration, the High Molecular Weight HA is taken up in connective tissue.

HA (Hyaluronic Acid) is a large, unsulfated glycosaminoglycan ubiquitously found in animals but concentrated in synovial fluid, vitreous humor and skin. Sodium Hyaluronate (SH) is the sodium salt of hyaluronic acid, habitually also called HA.

In the United States, HA is widely used in dietary supplements targeted for joint health and skin care, and millions of servings are consumed yearly. Although a few published reports of oral HA use found benefits for connective tissues, there has been limited evidence in the literature for uptake into tissues after oral administration of high molecular weight HA.

High-molecular weight HA (HyaMax®, 1MDa) labeled with 99mTechnetium (99mTc-HA) or free 99mTechnetium pertechnetate (99mTc) was administered to rats and dogs to confirm an earlier study finding regarding uptake of oral HA, and to control for possible loss of label. This report was able to present evidence of a 13.3% uptake of an oral dose of high-molecular-weight HA (HyaMax®), with particular accumulation in connective tissues.

The findings support a rationale for biological actions seen in animal and human studies. The findings support the application of HA in dietary supplements or functional foods designed for joint and skin health. Fenchem currently holds a significant share of the US and North American sodium hyaluronate markets, respectively.

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