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Magtein shows good results in rat cognition study

Researchers have known for some time that magnesium is essential for proper brain function. A new high-bioavailability magnesium functional ingredient called Magtein; distributed by leading ingredient supplier AIDP, Inc. has been shown in a recent animal study to significantly elevate brain levels of magnesium.


Researchers have known for some time that magnesium is essential for proper brain function. Yet because oral magnesium does not sufficiently raise brain magnesium levels, magnesium supplements have been of little use for enhancing cognitive function. Now, a new high-bioavailability magnesium functional ingredient called Magtein™, distributed by leading ingredient supplier AIDP, Inc. (, has been shown in a recent animal study to significantly elevate brain levels of magnesium.* As a result, Magtein markedly improved learning and memory in animals fed the ingredient.

Magnesium is an essential mineral that is a cofactor for over 300 enzymes and is needed for the proper functioning of many systems, including the nervous system. Magtein, or Magnesium L-threonate, is a magnesium salt of L-threonic acid, a vitamin C metabolite. It was developed by a group of scientists from the Massachusetts Institute of Technology—including Nobel Prize winner Susumu Tonegawa—who wanted to create a highly bioavailable magnesium compound that could significantly increase brain levels of magnesium through dietary supplementation.

“The level of magnesium in the brain is very different from the level of magnesium in the blood,” comments Dr. Jennifer Gu, PhD, Director of Research and Development for AIDP. “The reason is the blood-brain barrier.” Dr. Gu explains that ordinary magnesium can’t pass through this semi-permeable membrane, which is very particular about which substances it allows to enter the brain. “Unlike other forms of magnesium, however, Magtein has a very high brain bioavailability, meaning it can penetrate the blood-brain barrier and raise brain magnesium levels for long enough to improve cognitive function,” says Dr. Gu.

The results of the recent study on Magtein, published in the highly respected journal Neuron, showed that Magtein increased learning ability, working memory and short- and long-term memory in both young and aged rats.* This would suggest that Magtein has indications for enhancing cognitive function in people of all ages.* In addition, Magtein significantly elevated the magnesium concentration of the cerebrospinal fluid, while other forms of magnesium—including magnesium chloride and magnesium citrate—did not.*

How does Magtein work? The answer lies with synapses—those connections between brain cells that allow them to communicate with each other. Every day, we lose a stunning 10,000 brain cells, and with them, we lose synapses too. A decline in synapses is shown to correlate with mild memory problems associated with aging.

The researchers studying Magtein discovered that it increased synaptic density, meaning it boosted the number of synapses in the brain.* “When you have increased synaptic connections, more information will be transmitted through the brain cells,” explains Dr. Gu. “And that synaptic density has been shown to be associated with increased memory.” It’s as if before taking Magtein, information had to pass through a crowded one-lane road, resulting in a bottleneck, while after taking Magtein, new lanes of traffic opened up, creating a highway for increased transmission of information.

“In scientific publications, it is known that increased synaptic density is physical evidence for increased memory. So it’s a very big deal if something can increase synaptic density,” comments Dr. Gu. She’s not the only one who thinks so. Susumu Tonegawa, the Nobel Prize winning author of the study, noted, “This study not only emphasizes the importance of adequate dietary magnesium, but also indicates the benefits of magnesium-based medicine in addressing aging-related memory decline.” *

As exciting as these results are, the research on Magtein has only just begun. Two additional animal studies are in the process of being published in top journals, and a human clinical trial on Magtein’s effect on memory and cognitive function is currently underway.

Available exclusively through AIDP, Magtein is self-affirmed GRAS and protected by worldwide patents, with seven U.S. patents pending. Tasteless, odorless and colorless, it is easily added to a wide range of dietary supplements, beverages and functional foods aimed at enhancing cognitive function.

About AIDP, Inc.

AIDP has been a trusted source for core functional ingredients since 1996. Developing solid research breakthroughs and proprietary ingredients under the anti-aging platform for bone and joint health as well as cognitive function, AIDP aims to achieve ultimate customer satisfaction through creative product innovation and superior service.

For more information about AIDP call 303-734-0860 or visit

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