Phoenix, Ariz.—A breakthrough mechanism of action study indicates that SierraSil™, a new, unique mineral supplement, when used alone or in conjunction with Vincaria®, a patented alkaloid-removed cat’s claw extract, suppresses cartilage degradation and inflammation. The findings are published in the current edition of the Journal of the American Nutraceutical Association (JANA).
This in vitro tissue explant study, conducted in collaboration with researchers at Case Western Reserve University School of Medicine, utilized human cartilage tissue and cells obtained from patients at the time of knee surgery. Results show that both SierraSil and SierraSil with Vincaria significantly reduced the breakdown of cartilage structural integrity by 68-73% (SierraSil alone) and 58-77% (SierraSil with Vincaria) caused by the pro-inflammatory cytokine Interleukin 1β.
“These results indicate that SierraSil and SierraSil with Vincaria are likely to be effective anti-inflammatory agents in the treatment of joint pain and that these benefits are likely due to suppression of gene expression,” said Mark Miller, Ph.D., Professor of Cardiovascular Sciences and Pediatrics at Albany Medical College (NY).
Miller, a current grant reviewer for research for the National Institutes of Health (NIH), was the lead researcher and reporter for this mechanism of action study. “SierraSil and SierraSil with Vincaria may offer exciting new approaches to limiting the joint destruction and lack of mobility associated with arthritis,” Miller said.
SierraSil, a powerful, fast-acting, uniquely balanced blend of 65 naturally occurring macro and trace minerals, is only found in the high Sierra Mountains. SierraSil is a distinct mineral compound shown to support joint mobility and flexibility.
Vincaria is a proprietary alkaloid-removed extract of the Uncaria guianensis species of cat’s claw, which has been traditionally used as a medicinal herb in Central and South American indigenous populations.
SierraSil for this study was provided by Sierra Mountain Minerals, Inc., a Vancouver-based nutraceutical company. Vincaria for this study was provided by Rainforest Nutritionals, Inc., a Phoenix-based nutraceutical and clinical research company.
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 Miller, Mark J.S., Ahmed, S. et al. 2004. Suppression of Human Cartilage Degradation and Chondrocyte Activation by a Unique Mineral Supplement (SierraSil™) and a Cat’s Claw Extract, Vincaria®. Journal of the American Nutraceutical Association. Vol 7. No. 2:32-38.
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