New Research Shows Zenergen(TM) Effective For Weight Loss

Results Presented at the 1st Annual World Congress on the Insulin Resistance Syndrome

PURCHASE, NY, December 17, 2003 – Nutrition 21, Inc. (Nasdaq: NXXI), announced promising new research showing that Zenergen™, Nutrition 21’s proprietary blend of Chromax® chromium picolinate and Tonalin® CLA (conjugated linoleic acid), may reduce fat and enhance weight loss. The findings were presented in November 2003 at the 1st Annual World Congress on the Insulin Resistance Syndrome, in Los Angeles, Calif., by Dr. Vijaya Juturu, Nutrition 21, Inc.

According to Nutrition Business Journal, the weight loss and sports nutrition market is now $14.1 billion in sales driven by a population of 108 million people in the U.S. who are overweight. “This confirmation of our discovery is a welcome one,” says Gail Montgomery, President and CEO. “Consumers are searching for ephedra-free ingredients that work,” adds Montgomery. “Zenergen is a powerful new tool for active, health-conscious Americans who want to responsibly achieve their weight-loss goals using safe, effective and well-researched products.”

These in vitro and animal data, built on earlier experimental studies, suggest that Zenergen enhances carbohydrate metabolism, a key factor in weight loss, and improves body composition. Founded upon strong science linking Chromax and enhanced insulin sensitivity, the animal data presented strongly support the synergistic effects of the unique formulation of Zenergen for weight loss, superior to the benefits of each nutrient alone. In addition, a human clinical trial is scheduled for completion in early 2004, one which is expected to further validate Zenergen’s weight-loss benefits.

Chromax® chromium picolinate is the most clinically tested brand of chromium with proven efficacy for the support of glucose metabolism. Tonalin® (Cognis, La Grange, Ill.) is widely researched and is the best-known brand of CLA. Zenergen™ is composed of 400 mcg of Chromax and 2,400 mg of Tonalin in a special ratio found, in published experimental research, to reduce body fat while maintaining lean muscle mass.

About Nutrition 21
Nutrition 21 is an industry leader in using pharmaceutical quality research to substantiate the health benefits of nutritional supplements. It holds 24 patents for chromium compounds and their uses, and 11 other nutrition patents. The Company's proprietary technologies focus on chromium picolinate and its relationship to insulin resistance, a condition implicated in type 2 diabetes, cardiovascular disease, obesity and depression. Nutrition 21 markets Chromaxâ chromium picolinate, the leading chromium ingredient used in supplements. More information is available at and

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