New Study Finds Chromium Picolinate and Conjugated Linoleic Acid Combination Enhances Muscle Glycogen Production

Results from University of Vermont Medical College/Nutrition 21 Study Presented at American Diabetes Association Scientific Sessions

New Orleans, June 16, 2003 (Nutrition 21, Inc. Nasdaq: NXXI) – The results of a new study found the novel combination of chromium picolinate and conjugated linoleic acid (CLA) increased muscle glycogen levels -- a measure of the body’s ability to process stored glucose, which contributes to physical strength and endurance. The findings were presented Saturday, June 14 at the American Diabetes Association (ADA) 63rd Scientific Sessions in New Orleans by Dr. Vijaya Juturu, Nutrition 21, Inc. researcher, who collaborated with the University of Vermont Medical College on the study.

Chromium picolinate and CLA have independently shown benefits in improving glucose uptake in insulin-stimulated cells. The new study evaluated the effects of the nutrient combination on glycogen in human skeletal muscle cells. Researchers found that the combination of chromium picolinate and CLA significantly enhanced insulin-stimulated muscle glycogen production, more than when each was used alone.

“These results build upon previous studies showing that the combination of chromium picolinate and CLA has significant benefits in enhancing carbohydrate metabolism,” states James Komorowski, MS, Vice President of Technical Services and Scientific Affairs, Nutrition 21, Inc. “Enhancement in muscle glycogen levels is important for endurance, body building, and muscle recovery.”

The research was supported by an unrestricted grant to the University of Vermont Medical College from Nutrition 21, Inc. Nutrition 21’s novel combination of Chromax® chromium picolinate and CLA, known as Zenergen®, was used in the study.

“This research is part of Nutrition 21’s continued commitment to further validate the potential of chromium picolinate – individually and in novel ingredient combinations – as a nutritional supplement to enhance insulin function,” said Gail Montgomery, president and CEO. “The potential of Zenergen shows promise as a safe and effective supplement for active, health-conscious Americans.”

Chromium is an essential mineral that is a co-factor of insulin. Chromax chromium picolinate is the most clinically tested brand of chromium with proven efficacy for support of glucose metabolism.

About Nutrition 21

Nutrition 21 is a leading developer and provider of nutritional products whose health benefits are substantiated by clinical research. The Company markets Chromax chromium picolinate, the leading brand of chromium, and holds 35 patents for nutrition products, 22 for chromium compounds and their uses. More information is available at

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