Part 5: Science, Research and Technology (June 2005)

Companies in the News: The Quigley Corporation, Symrise GmbH & Co. KG, Nutrition 21, Inc., Polyphenolics, Constellation Wines U.S., NutriPharma, Advitech Inc., Proliant Health Ingredients, HerbalScience LLC, Pharmanex, Nu Skin Enterprises.

[6/29/2005] The Quigley Corporation Announces Results of Animal Model Inflammation Studies of Its QR440 Botanical, Anti-Inflammatory Compound
US-based health products company The Quigley Corporation (Nasdaq: QGLY) has announced results from a series of In-Vivo (animal model) inflammation studies on the company's botanical compound (QR440) finding that Delayed-Type-Hypersensitivity T cell response was reduced in mice, and granulyte movement to an inflammation site was also reduced.
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[6/29/2005] 'LC Taste(TM)' From Symrise a Breakthrough in Objective Sensory Analysis of Food Products
Germany-based Symrise GmbH & Co. KG has introduced a new high-temperature liquid chromatography method known as 'LC Taste(TM)', which allows researchers to separate aroma chemicals and flavoring components from solutions using a non-toxic blend of solvents.
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[6/27/2005] New Study Published In Leading Journal Reinforces Safety Of Chromax(R) Chromium Picolinate
US-based Nutrition 21, Inc., (NASDAQ: NXXI) has announced the results of a study to be published in an upcoming issue of Mutation Research Genetic Toxicology and Environmental Mutagenesis, indicates that the company's Chromax product did not cause genetic damage in hamster ovary cells. According to the company, the study was conducted at the request of the United Kingdom (UK) Food Standards Agency (FSA) to repeat a previously published study showing DNA damage.
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[6/22/2005] UC Davis Studies Show That Grape Seed Extract May Inhibit Artery Hardening
A series of three studies, funded by US-based Polyphenolics, a division of Constellation Wines U.S. and presented at the Experimental Biology Conference earlier this year, examine the effect of grape seed extract on cardiovascular health. In two of the studies, guinea pigs were used to compare the cholesterol accumulation caused by high-fat diets to those resulting from high-fat diets supplemented with grape seed extract, while the third in-vitro study showed that grape seed extract reversed the inhibitory effect that fatty acids in coconut oil had on endothelial function in rabbits, suggesting an effect on cardiovascular health.
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[6/21/2005] Study: Extra Folic Acid May Help Memory
According to an AP article on Yahoo News citing a study by researchers at Wageningen University in the Netherlands and presented at a meeting of Alzheimers researchers earlier this week, high dose folate pills might help slow the cognitive decline associated with aging. According to the researchers, who studied 818 cognitively healthy people (ages 50-75) receiving either 800 micrograms of folate or a placebo daily, those supplementing with folate performed better on memory and cognitive speed tests.
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[6/21/2005] China: Cardiovascular Drug Derived From Dan Shen (Saliva miltiorrhiza)
According to an article on News-Medical.Net, researchers at China's CAS Shanghai Institute of Materia Medica (SIMM) have submitted and had a proved, a New Drug Application (NDA) for depsides salts from Dan Shen (Salvia miltiorrhiza) for the treatment of chronic angina. According to the article, the researchers identified the most active component in the herb (long used in China to support cardiovascular health), and subsequently developed a novel extraction technology to obtain depsides salts from Salvia miltiorrhiza with magnesium lithospermate B as the primary active component. The researchers use fingerprint technology to measure magnesium lithospermate B for quality control.
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[6/17/2005] Therapeutic role of coenzyme Q10 in Parkinson's disease
Researchers at the University of California, San Diego, in a study reported in Pharmacology & Therapeutics (Volume 107, Issue 1 , July 2005, Pages 120-130) examine the effect of coenzyme Q10 in Parkinson's Disease and whether it can slow progressive disability. In this Phase II clinical trial involving patients with untreated Parkinson's Disease, coenzyme Q10 was associated with a slowing of progressive disability.
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[6/17/2005] Study of Milk-Based versus Soy-Based Liquid Meal Replacement Interventions
Researchers at the University of Kentucky, using a soy-based meal replacement product licensed from Norway-based NutriPharma, compared the effects of milk-based versus soy-based meal replacements on weight loss and serum protein changes for obese subjects on low-energy diets. The results, reported in the Journal of the American college of Nutrition (Vol. 24, No. 3, 210-216 (2005)) suggest that the soy meal replacement led to a significant reduction in serum triglycerides at 6 and 12 weeks, a significant reduction is serum cholesterol and LDL cholesterol and a small but not significantly greater weight loss over a twelve week period
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[6/16/2005] Advitech Announces Completion of 2nd Study on XP-828L For Psoriasis
Canada-based biotechnology company Advitech Inc. (TSX-V: AVI) has announced that the treatment phase of its double-blind, placebo-controlled, randomized clinical trial for XP-828L, the company's oral treatment for mild-to-moderate psoriasis, has been concluded with results to be released July 5, 2005.
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[6/15/2005] Fish Oil Supplementation and Risk of Ventricular Tachycardia and Ventricular Fibrillation
Researchers from the VA Medical Center in Portland, Oregon, in a study published in the Journal of the American Medical Association (JAMA) examined 200 patients with implantable defibrillators to determine whether supplementation with fish oil would lead to a reduction in the risk of ventricular tachycardia or ventricular fibrillation. The subjects received either 1.8g/day of fish oil or placebo. The results indicated that supplementation had no effect and the researchers noted that recurrent events were more common in patients receiving the fish oil.
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[6/14/2005] Vitamin B6 May Reduce Colon Cancer Risk in Women
According to a Reuters Health article citing the journal Gastroenterology (June 2005), researchers from Sweden's Karolinska Insititute have determined that women with higher dietary vitamin B6 appear to have a lower risk of developing colorectal cancer. According to the article, the researchers analyzed data from 61,433 women who participated in the Swedish Mammography Cohort, aged between 40 and 76 years of age and cancer-free when they enrolled. Women with the highest long-term level of vitamin B6 intake were 34% less likely to develop colorectal cancer than women at the lowest intake level.
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[6/14/2005] Calcium and Vitamin D Intake and Risk of Incident Premenstrual Syndrome
According to researchers at the University of Massachusetts, published in the June 13 issue of Archives of Internal Medicine examining the effect of calcium and vitamin D intake on the risk of incident premenstrual syndrome (PMS), there appears to be a correlation between intake of Vitamin D as well as calcium from food sources and a lowering of risk related to PMS. The researchers evaluated the diet and supplement use of 1,057 women from 27 to 44 years of age who reported having PMS over a course of ten years against 1,968 women who did not report PMS during the same period.
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[6/13/2005] Clinical Trial Shows Diachrome Improves Diabetes Care for Patients with Poorly-Controlled Blood Sugar Levels on Prescription Medications
US-based Nutrition 21, Inc. (NASDAQ:NXXI) has reported results from a new clinical trial that indicate that daily supplementation with Diachrome(R) can improve uncontrolled blood sugar levels and cardiovascular risk factors in people with type 2 diabetes on prescription medications in a managed care setting. According to the company, the current study evaluated 369 subjects and was presented at the American Diabetes Association (ADA) 65th Annual Scientific Sessions in San Diego, CA.
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[6/9/2005] Study Suggests That Raisins May Fight Cavities and Gum Disease
According to a Reuters article, compounds in raisins suppress bacteria that cause cavities and gum disease. According to the article, citing research presented at the meeting of the American Society for Microbiology, five compounds (oleanolic acid, oleanolic aldehyde, betulin, betulinic acid and 5-(hydroxymethyl)-2-furfural) seem to make teeth and gums healthier, in the case of oleanic acid, by slowing growth of a cavity causing bacteria and inhibiting the bacteria from sticking to surfaces.
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[6/9/2005] Indian Scientists: Black Tea May Prevent Oral Cancer
According to an article on, research by scientists at India's Vivekanada Institute of Medical Sciences, published in the latest issue of the Journal of Environmental Pathology, Toxicology and Oncology, suggests that polyphenols in black tea might help prevent oral cancer. According to the article, the current study involved 15 patients with potentially pre-cancerous Leukoplasia, who consumed black tea three times daily for one year, with changes observed in the white spots indicative of Leukoplasia, (of which half will typically lead to oral cancer), or the disappearance of the spots entirely.
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[6/8/2005] Inhibitory Effect Of Garlic Extract On Oral Bacteria
According to an article on Biocompare citing the Archives of Oral Biology, researchers examined the ability for a filter sterilized, aqueous extract of garlic to inhibit the growth of a range of oral bacteria and to inhibit trypsin-like and total protease activity Porphyromonas gingivalis. The researchers observed that garlic extract inhibits the growth of oral pathogens and certain proteases and may have therapeutic value, particularly for periodontitis.
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[6/8/2005] Capsaicin Lozenge May Prevent Aspiration in Elderly
According to a Reuters Health article, citing a study published in Journal of the American Geriatric Society, researchers from Tohoku University School of Medicine in Sendai, Japan monitored 64 nursing home patients (average age 82 years) who received either a capsaicin or a placebo lozenge for four weeks, to be dissolved in the mouth before every meal. The researchers observed that the capsaicin lozenge statistically improved the reflexes of the upper respiratory system, which may help prevent aspiration and pneumonia in the elderly and assist those who have trouble swallowing.
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[6/7/2005] Low-Glycemic Diet Studied
According to a Reuters Health article reporting the results of a study on 23 obese adults following either a low-fat diet or one in which the participants ate low-glycemic index foods for one year, researchers had the low-fat participants cut their daily intake by 250 to 500 calories, limit their fat to less than 30 percent of total calories, and receive between 55 and 60 percent of calories from carbohydrates. Low-glycemic participants could eat as much as they wanted of foods with a low index, and received 45 to 50 percent of calories from carbohydrates, and 30 to 35 percent from fat. The researchers noted that when obese people consumed as many carbohydrates with a low-glycemic index as they wanted, they lost just as much weight in 12 months as people who were on the low-fat diet. (American Journal of Clinical Nutrition, May 2005)
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[6/7/2005] Omega-3 and Drug Combination Studied as Anti-breast Cancer Treatment
According to an article on Medicalnewstoday, citing research published in the journal Breast Cancer Research, researchers from from the Methodist Research Institute and Indiana University have examined the effect of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), combined with propofol, a commonly used anesthetic) on a breast cancer cell line in vitro. The researchers noted that the combination appeared to reduce the ability of breast cancer cells to develop into malignant tumours, inhibited cell migration and reduced metastatic activity.
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[6/7/2005] Irritable Bowel Syndrome (IBS) Study - Recruiting Completed
Proliant Health Ingredients has announced completion of recruiting for their Irritable Bowel Syndrome (IBS) Clinical Trial utilizing the company's ImmunoLin ingredient.
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[6/7/2005] Cranberry Juice May Help Beat Gut Disorders
According to an article on, research presented at the American Society for Microbiology meeting suggests that adding cranberry juice to intestinal viruses in laboratory conditions blocked their ability to infect intestinal cells. The researchers from St Francis College in New York suggest that the cranberry juice might destroy or modify receptor sites on the host cells to which viruses usually bind, or damage the protein docking mechanism of the virus itself.
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[6/6/2005] Low Zinc Intake May Sap Exercisers' Energy
According to a Reuters Health article, researchers at the U.S. Department of Agriculture, in a study reported in the American Journal of Clinical Nutrition, have determined that active people with low levels of zinc in their diets seem to run out of energy compared to cardiac performance on a zinc-fortified diet. The study examined 14 young men over a nine week period, and measured their cardiovascular performance on both a zinc-deficient and zinc-fortified diet.
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[6/6/2005] China Reports Progress in Modernizing Traditional Chinese Medicine
According to an article in China's People's Daily, efforts ot modernize China's traditional Chinese medicine (TCM) industry are moving steadily forward. According to the article, 448 standardized planting bases have been built in 18 provinces, municipalities and autonomous regions where 933,333 hectares of medicinal herbs have been grown, statistics from the State Intellectual Property Office of China showed there were 4,520 applications for patents in 2004, with the State Food and Drug Administration approved 203 kinds of new TCM products for sale in that year.
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[6/6/2005] Singapore Company Developed 'Fingerprinting' Technology
According to an article in Singapore's The Business Times, that country's HerbalScience LLC is in the process of developing and commercializing a technology which uses supercritical carbon dioxide processes to standardize botanical samples to a specific chemical profile. The company has filed 36 patents with the US Patent Office, based on the profiles it has discovered for herbs such as turmeric, green tea and ginseng, with several ready for production and the market by the end of the year. According to the article, the company has developed a delivery system called 'Herbalvesent', an oral, quick-dissolving tablet designed to offer higher bioavailability and hence lower dose.
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[6/3/2005] Fatty Acids May Be Key to Unlock Autism
According to a United Press International article on, Scottish researchers at the University of Stirling, in a pilot study, have determined that childhood autism might be linked with a deficiency of fatty acids found in oily fish, suggesting that children with autism had cells that broke down fatty acids more rapidly than normal cells.
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[6/2/2005] Study on Pharmanex Tegreen 97(R) Finds Benefits in Blood Sugar Control and Weight Loss
Pharmanex, a subsidiary of direct selling Nu Skin Enterprises (NUS), has presented the results of a study at the American Heart Association's Sixth Annual Conference indicating that the company's Tegreen 97(R) product provides blood sugar control, body fat burning properties and weight-loss benefits in an experimental setting of Metabolic Syndrome X subjects.
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