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Part 5: Science, Research and Technology (Mar. 2005)

Companies in the News: PL Thomas, Nurture, Inc., Mars, Incorporated, General Mills, Next Pharmaceuticals, PharmaNutrients, Inc., CV Technologies Inc.

[3/31/2005] Sunburn and Sun Allergy May be Inhibited by GliSODin
According to a release issued by US-based ingredient company PL Thomas, a recently concluded 60-day study of 150 volunteers, conducted by French dermatologists, suggests that might offer some protection for individuals susceptible to flushing and burns, sun allergy, and other reactions, potentially by preparing the skin for exposure and oxidative stress.
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[3/31/2005] New Research Surrounding Oil Palm Trunk Fiber to Be Presented at FASEB Conference
New research surrounding oil palm trunk fiber will be presented as part of a panel presentation entitled "Dietary Fiber, Fruits, Vegetables and Grains I" at the Federation of American Societies for Experimental Biology (FASEB) conference on Monday, April 4, 2005 at the San Diego Convention Center.
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[3/30/2005] A Tool to Fight Cholesterol
According to a release issued by US-based ingredient company Nurture, Inc., results from a new double-blind clinical research study to be released in April indicate that adults with elevated cholesterol can incorporate significant amounts of concentrated oats into their diet and achieve a significant reduction in LDL cholesterol. The latest study, conducted using the company's OatVantage ingredient, will be reviewed at the Experimental Biology 2005 Conference April 2-6 at the San Diego Convention Center.
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[3/30/2005] New Monthly Journal for Naturopaths to Launch
A new natural medicine publication, ND News & Review, is set to launch this coming June., targeted at being a monthly trade publication for Naturopathic Doctors. According to the release issued, the journal will feature industry news and regular topics such as research, practice management, case studies, and business development.
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[3/29/2005] Vitamin B12 Deficiency Associated with Low Bone Mineral Density in Men
According to an article on Food Ingredients First, a new study reported in the Journal of Bone and Mineral Research has linked vitamin B12 deficiency with low bone mineral density in men, at the same time confirming previous findings for women.
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[3/25/2005] Study Finds Cocoa Flavanols May Lower Blood Pressure, Improve Insulin Response
A release issued by Mars, Incorporated notes a study from Italy's University of L'Aquila, published in this month's American Journal of Clinical Nutrition which confirms that flavanol compounds found in certain cocoa and chocolates provide heart health benefits. According to the release, Mars' Cocoapro(R) cocoa process is used in the chocolate in a new cocoa-based snack bar called CocoaVia(R).
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[3/23/2005] Study Examines Yogurt and Loss of Body Fat
According to a Reuters Health article, a study published in the International Journal of Obesity (April 2005) examined 34 men and women on a 12-week reduced calorie diet, finding that those who ate three servings of yogurt per day shed 61% more in fat pounds, and 81% more abdominal fat than those who did not consume the yogurt (only one dairy serving per day plus an additional 500mg of calcium). Each group had 500 calories cut from their daily diet. The research was funded by General Mills, maker of Yoplait yogurt.
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[3/23/2005] Study Examines Effect of Pomegranate Juice on Cardiovascular Risk
Research published in the Proceedings of the National Academy of Sciences (Proc. Natl. Acad. Sci. USA, 10.1073/pnas.0500998102) examined the effect of pomegranate juice on the progression of atherosclerosis in mice, finding that hypercholesterolemic mice that drank the pomegranate juice reduced the progression of atherosclerosis (plaque buildup) by 30%. The researchers also found that heart cells treated with the juice had a 50% increase in nitric oxide production. According to a HealthDay news article on Yahoo, the equivalent amount of pomegranate juice in humans would be approximately 16 ounces daily.
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[3/23/2005] High DHA Diet Reduced Amyloid Protein Buildup
According to a HealthDay News article, citing the March 23 online issue of the Journal of Neuroscience, research on mice has examined the effect of feeding mice food fortified with docosahexenoic acid (DHA), noting that after three to five months, (translating to several years in humans) the group fed the DHA-rich diet had 70% less amyloid protein buildup in the brain, compared to the group fed a low-DHA diet. The researchers noted this effect, even when the feeding started with older mice. Amyloid protein contributes to the plaque in the brain associated with Alzheimer's Disease.
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[3/17/2005] Study Examines Seditol(TM) For Improving Sleep and Reducing Fatigue
According to a release issued by US-based Next Pharmaceuticals, a human study conducted on 45 subjects by an independent contract research organization has indicated that the company's natural ingredient Seditol(TM) is effective for ensuring a sound night’s sleep and allowing adults to wake up feeling refreshed.
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[3/16/2005] Effects of Long-term Vitamin E Supplementation on Cardiovascular Events and Cancer
A study reported in JAMA (JAMA. 2005;293:1338-1347) examined whether long-term supplementation with vitamin E decreases the risk of cancer, cancer death, and major cardiovascular events, using patients who had participated in the initial Heart Outcomes Prevention Evaluation [HOPE] trial conducted between December 21, 1993, and April 15, 1999, by following some of these patients for an additional seven years as they consumed a daily dose of natural source vitamin E (400 IU) or matching placebo. According to the researchers, in the group receiving vitamin E, there were no differences in cancer incidence, cancer deaths, and major cardiovascular events, but higher rates of heart failure and hospitalizations for heart failure. The Council for Responsible Nutrition (CRN) notes that the study involves elderly patients with a history of heart disease and stroke.
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[3/15/2005] Study of Obese Diabetics Explains Why Low-Carb Diets Produce Fast Results
Researchers at Temple University School of Medicine, in a study published in the March 15 issue of the Annals of Internal Medicine have examined a group of obese patients with type 2 diabetes who followed the Atkins diet. The researchers concluded that excessive overeating had been fueled by carbohydrates and the researchers also noted that the subjects experienced improved glucose levels and insulin sensitivity, as well as lower triglycerides and cholesterol.
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[3/11/2005] Study Suggests European Folic Acid Policies Are Not Effective Enough
According to an article on Medical News Today citing this week's British Medical Journal (2005;330:574-575 ) as the source, the prevalence of neural tube defects in 16 European countries have not declined substantially between 1980 and 2001. According to the article, Neural tube defects in Continental Europe remained the same in the past decade, and although defects in the UK and Ireland fell by 32%, levels are higher there than in continental Europe. The researchers conclude that folic acid supplementation policies are inadequate, and women of childbearing age may be unaware that changes in diet alone are unlikely to achieve sufficient folate intake.
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[3/11/2005] New Research: Almonds Boost Vitamin E Intake and Lower Cholesterol
According to a study conducted by researchers at Loma Linda University and published in the Journal of the American Dietetic Association (Vol. 105, No. 3, 449-454, March 2005 ), eating almonds significantly increases vitamin E levels in the plasma and red blood cells and simultaneously lowers cholesterol levels. The researchers found that when study participants consumed 10% of their calories from almonds, vitamin E levels increased 13.7%, and when 20% of calories came from almonds, vitamin E levels rose 18.7%.
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[3/9/2005] New Study Shows GliSODin® Supplementation Increases SOD Levels and Protects Against Oxidative Stress
Ingredient company PL Thomas has announced the results of a new study using its GliSODin® ingredient, concluding that supplementation with GliSODin® promoted cellular antioxidant status and protected against oxidative stress-induced cell death. The mouse study is published in Phytotherapy Research (March 1, 2005) and shows that Supplementation with GliSODin in normal mice for 28 days was found to promote the antioxidant enzymes SOD, catalase and Gpx.
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[3/7/2005] St John's wort Amplifies Affect of Blood Thinner
According to an article on, researchers from the University of Michigan Cardiovascular Center have determined that St John's wort appears to amplify the action of the popular blood-thinning drug clopidogrel (Placix). According to the researchers, who examined six volunteers with a low response to clopidogrel, these subjects showed a marked decline in platelet aggregation after taking 300mg of St. John's wort three times daily for two weeks, followed by 450mg of clopidogrel. The scientists suggest more work is required, while noting that in most cases of interactions, St. John's wort appears to decrease the activity of a medication, rather than increasing it.
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[3/7/2005] 85-Year-old Black Cohosh Root Still Contains Active Compounds
A recent study by researchers at The New York Botanical Garden (NYBG), Lehman College, City University of New York, and Columbia University and published in the Journal of Ethnopharmacology, has found that an 85-year-old specimen of black cohosh root still contains much of its naturally-occurring chemical compounds. The sample was analyzed for its triterpene glycosidic and phenolic constituents - compounds believed to be responsible for the root's medicinal activity, and compared with a recently collected sample. The analysis showed that both plant samples had similar amounts of the four major triterpene glycosides, but the total amount of the six major phenolic constituents measured in the 85-year-old plant material was lower than the amount in the modern plant material.
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[3/4/2005] Daily Supplement May Boost Birthweight of Babies In The Developing World
According to a study published online in the journal the Lancet, a daily supplement containing 10 vitamins and five minerals, given to pregnant women in the developing world, could help increase the birthweight of their babies. According to the study, women received either a supplement containing 10 vitamins (vitamin A, E, D, B1, B2, B6, B12, C, niacin, folic acid) and five minerals (iron, zinc, copper, selenium, iodine) or tablets containing iron and folic acid, once daily for an average of 160 days. Those receiving the supplement had an average birthweight 77g higher than in the control group, which according to the researchers would mean a 25% reduction in the prevalence of low birthweight.
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[3/4/2005] PharmaNutrients Launches New CLA Technology: Dual Mechanism CLA One(R) DG
US-based ingredient company PharmaNutrients, Inc. has announced the launch of CLA One DG, a patented technology that delivers the company's CLA One product as a diglyceride suitable for use in dietary supplements and foods, and provides attributes of a diglyceride oil.
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[3/4/2005] Report Examines Echinacea Research
A Reuters Health article on Yahoo News cites research published in Clinical Infectious Diseases, March 15, 2005, which suggests that most of the major studies on echinacea are severely flawed, and that in the only two of the nine studies the researchers examined that in their opinion were not flawed, the results did not determine that echinacea was effective.
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[3/2/2005] Folate and Vitamin B12 Cut Post-stroke Hip Fracture Risk
According to a Japanese study published in the Journal of the American Medical Association (JAMA 2005;293:1082-1088,1121-1122.) dietary supplements folate and vitamin B12 can reduce the incidence of hip fracture in elderly patients after stroke. The researchers, in a double-blind randomized controlled study of 628 patients, observed that those treated with 5mg folate and 1500ug of vitamin B12 had their homoscysteine levels decrease by 38%, compared to a 31% rise in the placebo group, which led to a relative risk of 0.20 for hip fracture compared to the placebo group, (Absolute risk reduction 7.1%) with no adverse effects.
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[3/2/2005] Vitamin D Injections May Significantly Improve Survival in Dialysis Patients
According to a study conducted by researchers at Massachusetts General Hospital, scheduled to be published in the April Journal of the American Society of Nephrology, 76% of dialysis patients receiving any form of activated vitamin D were still alive at the end of a two-year period, compared with 59% of those not receiving the therapy. According to the researchers, more studies, including randomized clinical trials are required.
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[3/1/2005] Scientific Experts Meet to Discuss Safety and Benefits of Vitamin E
Experts in pharmacology, toxicology and nutrition gathered at the University of Southern California this past weekend to discuss the benefits and safety of Vitamin E, concluding that antioxidant supplements are safe and appear to confer a health benefit in certain individuals, and that future research in well-defined populations with both clinical and biomarker end-points, needs to be undertaken.
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[3/1/2005] New Study Shows GliSODin(R) Inhibits DNA Damage Due to Ischemia-reperfusion Induced Oxidative Stress
US-based PL Thomas has announced results of an animal study conducted by researchers at the University of Ulm, Germany, presented at the Congress of the European Shock Society in Vienna, Austria, entitled "The Orally Effective Mixture of Sod and Gliadin (GliSODin®) Protects Against Oxidative DNA Damage." According to the researchers, pretreatment with GliSODin inhibits oxidative DNA damage related to induced ischemia-reperfusion injury, with the GliSODin group demonstrating significant DNA protection, and reduced oxidative DNA damage related to surgical stress and ischemia-reperfusion after aortic clamping, compared to placebo.
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[3/1/2005] COLD-fX(R) to be Studied as New Way to Protect Seniors from Influenza in Canadian Nursing Homes
Canada-based CV Technologies Inc.(TSX VENTURE:CVQ) has announced a project in collaboration with Capital Health to investigate the potential use of COLD-fX(R) as a "standard of care" for the prevention of upper respiratory infections in Canadian nursing homes. According to the company, the first phase of the project is a pilot clinical study among residents in up to four Edmonton area continuing care facilities to examine tolerability.
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