UK authors of a seminar article in this week's issue of THE LANCET highlight how rickets-often considered a disease of the past-is still a global public-health problem today. The authors propose the use of Vitamin D supplementation for pregnant women and among children up to the age of puberty to prevent a resurgence of the disease.
Vitamin D is essential for healthy bone formation during childhood; sources of vitamin D include natural synthesis as a result of skin exposure to sunlight, and limited food sources that include fortified cereals and oily fish.
Brian Wharton from the Institute of Child Health, London, and Nick Bishop from the University of Sheffield, UK, outline three main reasons which are contributing to an increase in vitamin D deficiency and rickets: the promotion of exclusive breastfeeding for long periods without vitamin D supplementation, particularly for babies whose mothers are vitamin D deficient; reduced opportunities for production of the vitamin in the skin because of female modesty and fear of skin cancer; and the high prevalence of rickets in immigrant groups in more temperate regions.
Nick Bishop comments: "A safety net of extra dietary vitamin D should be re-emphasised, not only for children but also for pregnant women. The reason why many immigrant children in temperate zones have vitamin D deficiency is unclear. We speculate that in addition to differences in genetic factors, sun exposure, and skin pigmentation, iron deficiency may affect vitamin D handling in the skin or gut or its intermediary metabolism."
Contact: Professor Nick J Bishop (only available up to 1500 H Thursday 23 October), Professor of Paediatric Bone Disease, Head, Academic Unit of Child Health, Sheffield Children's NHS Trust, Western Bank Sheffield S10 2TH, UK;
T) +44 (0)114 271 7228; F) +44 (0)114 275 5364; E) firstname.lastname@example.org or email@example.com