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Starch trumps alginate in lutein bioavailability

Study determined the starch matrix formulation in FloraGLO Lutein 5% was much more bioavailable than the alginate matrix utilized in Lyc-O-Lutein 20%.

DSM Nutritional Products is pleased to report that a revealing new study was published online in the European Journal of Nutrition that clearly demonstrates that not all sources of lutein are equivalent. This study adds to the body of scientific evidence demonstrating the importance of choosing a lutein source with proven absorption that will assure users they are in fact getting lutein’s important health benefits.

In this randomized, double-blind, crossover study conducted by lead author Dr. Malkananthi Evans and coauthors, the effect of formulation differences on the bioavailability of lutein was evaluated using a starch matrix FloraGLOLutein 5% and a alginate-matrix Lyc-O-Lutein 20%. Forty-eight healthy subjects were given a single dose of 20 mg lutein from either of the two formulations and lutein was measured in the plasma at several time intervals. After a wash-out period of 28 days, the study was repeated with the alternative formulation. The findings were highly significant. After 14 hours, total plasma lutein increased by 126 percent with the starch matrix FloraGLO Lutein 5% compared to only 7 percent with the alginate matrix Lyc-O-Lutein 20%. After 672 hours the area under the curve for total lutein was 1.3-fold higher for the starch-matrix FloraGLO Lutein 5% compared to the alginate-based Lyc-O-Lutein 20%.

The practical application of this study is highly relevant. Although lutein has demonstrated benefits in eye health it can only impart those benefits if this bioactive compound is efficiently absorbed by the body. This study shows that not all lutein sources are equivalent. Their bioavailability clearly depends on the formulation and in this study the starch matrix formulation was much more bioavailable than the alginate matrix utilized in the Lyc-O-Lutein 20% product. The benefits associated with FloraGLO lutein are based on a suite of high quality clinical studies. The above result is a further demonstration that not all brands can deliver these benefits; FloraGLO lutein has proven high bioavailability.

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