Study Suggests Link Between Vitamin B12 Level and Positive Treatment Outcome in Patients with Major Depressive Disorder

The study measured haematological indices, erythrocyte folate and serum vitamin B12 levels in 115 patients with DSM-III-R major depressive disorder at baseline and after six months, with results, measured by the Hamilton Depression Rating Scale indicating a significant correlation between higher vitamin B12 levels and better outcome.

The researchers conclude that vitamin B12 level and the probability of recovery from major depression may be positively associated, but further studies are suggested to confirm this finding.

Jukka Hintikka , Tommi Tolmunen , Antti Tanskanen and Heimo Viinamaki
BMC Psychiatry 2003, 3:17 (published 2 December 2003)

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