Tocopherol Manufacture by Tris(perfluorohydrocarbylsulphonyl) Methane or Metal Methides Thereof

Assignee - Roche Vitamins Inc.

April 16, 2002

Source: MicroPatent

U.S. Patents: Abstract: A method of making (all-rac.)-.alpha.-tocopherol by the acid-catalyzed condensation of trimethylhydroquinone with isophytol or phytol wherein the condensation is carried out in the presence of a tris(perfluoroalkanesulphonyl or pentafluorobenzenesulphonyl)methane or a metal salt thereof as the catalyst in an organic solvent. In addition to the metal salt, a Bronsted acid, e.g. sulfuric acid, phosphoric acid or p-toluenesulphonic acid, may be used as a co-catalyst. The product of the method of making is the most active member of the vitamin E group.

Ex Claim Text: A method of making (all-rac.)-.alpha.-tocopherol comprising: a) reacting trimethylhydroquinone (TMHQ) with isophytol (IP) or phytol (PH) in an organic solvent and in the presence of a tris(perfluoroalkanesulphonyl)methane, a tris(pentafluorobenzenesulphonyl)methane, a metal tris(perfluoroalkanesulphonyl)methide, or a metal tris(pentafluorobenzenesulphonyl)methide catalyst of formula I: [R.sup.1 SO.sub.2).sub.3 C].sub.x R.sup.2 I wherein R.sup.1 is a perfluoroalkyl group C.sub.n F.sub.2n+1 or pentafluorophenyl, R.sup.2 is a proton or a metal cation selected from the group consisting of boron, magnesium, aluminium, silicon, scandium, titanium, vanadium, vanadyl, manganese, iron, cobalt, nickel, copper, zinc, yttrium, zirconium, rhodium, palladium, silver, tin, lanthanum, cerium, praseodymium, neodymium, europium, dysprosium, ytterbium, hafnium, platinum, and gold, n is an integer from 1 to 10, and x is the corresponding valency of the proton (1) or metal cation (1, 2, 3, or 4); and b) isolating the (all-rac.)-.alpha.-tocopherol.

Patent Number: 6369242

Issue Date: 2002 04 09

If you would like to purchase a copy of this patent, please call MicroPatent at 800-648-6787.

Bonrath, Werner
Haas, Alois
Hoppmann, Eike
Netscher, Thomas
Pauling, Horst

Hide comments


  • Allowed HTML tags: <em> <strong> <blockquote> <br> <p>

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.