Research capsule


Study claims: 7-Keto reverses the decrease in resting metabolic rate (RMR) normally associated with dieting and increases RMR above basal levels of overweight adults.

Published: Zenk JL, et al. HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each increases the resting metabolic rate of overweight adults. J Nutr Biochem 2007 Sep;18(9):629-34.

Abstract: This study tested the hypothesis that 3-acetyl-7-oxo-dehydroepiandrosterone alone (7-Keto) and in combination with calcium citrate, green-tea extract, ascorbic acid, chromium nicotinate, and cholecalciferol (HUM5007) will increase the resting metabolic rate of overweight subjects maintained on a calorie-restricted diet. In this randomised, double-blind, placebo-controlled, crossover trial, overweight adults on a calorie-restricted diet were randomised to three seven-day treatment periods with 7-Keto, HUM5007 or placebo. Resting metabolic rate was measured by indirect calorimetry at the beginning and end of each treatment period with a seven-day washout between testing periods. During the placebo treatment, RMR decreased by 3.9 per cent (75+/-111 kcal/day); however, RMR increased significantly by 1.4 per cent (21+/-115 kcal/day) and 3.4 per cent (59+/-118 kcal/day) during the 7-Keto and HUM5007 treatment periods, respectively (each compared to placebo). No significant differences were found between the treatment periods with respect to compliance or adverse events. HUM5007 and 7-Keto increased RMR above basal levels and may benefit obese individuals with impaired energy expenditure. Both were generally well tolerated and no serious adverse events were reported.

Potential applications: 7-Keto can help boost energy expenditure, helping dieters to safely maximise weight loss.

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AloecorpStudy claim: Aloe vera is a powerful complement to other supplements, enhancing their absorbance and effects.

Published: Devaraj S, et al. Aloe supplements enhance bioavailability of vitamin C and B12 in older adults. FASEB J: Exp Biol 2007 Abstracts 8.1-701.35. ?Washington, DC; 2007;Apr 28-May 2.

Abstract: Vitamin/supplement intake is associated with decreased mortality. Aloe vera, a botanical is consumed by 50 per cent of the US population and may affect bioavailability of vitamins. In a small study, aloe improved vitamin C absorption. Since oral B12 is deficient in vegetarians and in ageing, we tested the effect of two aloe vera preparations compared to placebo on the bioavailability of vitamins, C and B12, in older healthy human volunteers. In a randomised cross-over trial, subjects (40—80 years, n=15) received either aloe whole leaf extract (AL with vitamins B12, 1mg, and vitamin C 500 mg) or aloe fillet gel (AG with vitamins) or water (with vitamins) and blood was obtained fasting and following 1, 2, 4, 6, 8 and 24 hours post-ingestion of aloe/water with 1 week between treatments.

AG and AL did not affect lipids or glucose. AG significantly increased plasma oxygen radical absorbance capacity (ORAC) at 4 and 24 hours while AL significantly increased it at 4 hrs compared to baseline and placebo (AUC, 24h). AG significantly increased plasma vitamin C at 4, 6, 8 and 24 hours and AL significantly increased it at 4 and 6 hours (AUC, 8 and 24 hours). AG and AL significantly increased serum vitamin B12 levels at 1 and 2 hours.

Aloe preparations are well-tolerated and enhance bioavailability of vitamins C and B12 and ORAC. This could have major implications with regards to supplementation of vitamins to target chronic diseases, especially in elderly.

Potential applications: Consuming aloe vera, in foods, beverages or supplements, along with vitamin supplements would be beneficial especially among populations for whom B12 deficiency is an issue, such as the ?elderly.

+1 800 458 2563

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