May 28, 2010
Vital stats: DSM's resVida brand resveratrol
Study claim: resVida is readily absorbed, well tolerated and non-toxic.
Published: Williams LD, et al. Safety studies conducted on high-purity trans-resveratrol in experimental animals. Food Chem Toxicol 2009 Sep;47(9):2170-82.
Abstract: Trans-resveratrol is a naturally occurring polyphenolic compound found in a variety of foods, but predominantly in grapes. Safety studies were conducted on high-purity trans-resveratrol (Resvida), including skin and eye irritation, dermal sensitisation, subchronic and reproductive toxicity, genotoxicity, absorption, metabolism and excretion. ResVida was nonirritating to skin and eyes, and nonsensitising. It was nonmutagenic in a bacterial reverse mutation assay in Salmonella typhimurium and Escherichia coli, but exhibited clastogenic activity in a chromosomal aberration test in human lymphocytes. However, in an in vivo bone marrow micronucleus test in rats, resVida was nongenotoxic. In a 28-day study, resVida caused no adverse effects in rats at 50, 150 and 500mg/kg body weight/day. Similarly, in a 90-day study, resVida did not cause any adverse effects in rats at up to 700mg/kg body weight/day — the highest dose tested. ResVida did not induce any adverse reproductive effects in an embryo-fetal toxicity study in rats at a dose of 750mg/kg body weight/day. Also, in vitro and in vivo absorption, metabolism and excretion studies in Caco-2 cells, rat primary hepatocytes and male and female rats (in vivo) show that Resvida is readily absorbed, metabolized and excreted. These studies provide evidence that Resvida is well tolerated and nontoxic.
Potential applications: Resveratrol has been demonstrated in various animal models to extend lifespan; improve cardiovascular health; improve balance, co-ordination and endurance; improve insulin sensitivity and glucose utilisation. ResVida is self-affirmed GRAS, is 99 per cent pure and is free from pesticide and herbicide residues.
Vital stats: Biothera's Wellmune WGP 1,3-1,6 beta-glucan
Study claim: Wellmune WGP, a natural carbohydrate that activates key immune cells, reduced the incidence of coldlike symptoms and improved the psychological well-being of individuals with stressful lifestyles.
Published: Talbott S, Talbott J. Beta 1,3/1,6 glucan decreases upper respiratory tract infection symptoms and improves psychological well-being in moderate to highly-stressed subjects. Agro Food Industry Hi-Tech 2010;21:21-24.
Abstract: A randomized, placebo-controlled, double-blind design study was conducted to evaluate the effect of b-1,3/1,6 glucan derived from baker's yeast, a dietary supplement, on symptoms associated with upper respiratory tract infections and psychological well-being. Moderate to highly stressed subjects (45 men, 105 women) ranging in age from 18—65 (mean age: 39 ± 11 years) were administered placebo, 250mg or 500mg beta-1,3/1,6 glucan during a four-week treatment period. Subjects in both treatment groups (250mg and 500mg beta-1,3/1,6 glucan per day) reported fewer upper respiratory tract infection (URTI) symptoms, better overall health and increased vigour, and decreased tension, fatigue and confusion based on the Profile of Mood States (POMS) assessment.
Specifically, after two weeks, 32 per cent of the subjects in the placebo group reported URTI symptoms, compared with only 10 per cent in the group taking 250mg Wellmune WGP. At four weeks, 28 per cent of the placebo group reported URTI symptoms, compared with eight per cent in the group taking Wellmune WGP. In addition, the Wellmune WGP group reported a 41 per cent increase in general health when compared with the placebo group over the four-week study period. In comparison with the placebo group, the Wellmune WGP group reported statistically significant increases in vigour, and reductions in fatigue (38 per cent), tension (19 per cent), and confusion (15 per cent).
The psychological health assessment was obtained with a POMS questionnaire, which measures vigour, fatigue, tension, confusion, depression and anger. The POMS profile has been used in more than 2,900 health studies.
Potential applications: For stress and immune health, Wellmune WGP is designed for foods, beverages and supplements.
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