Thrombosis and Haemostasis, The International Journal for Vascular Biology and Medicine, has approved for publication in its May 2015 print issue a new study showing the positive impact of MenaQ7® Vitamin K2 as MK-7 (menaquinone-7) on cardiovascular health.
The study titled “Menaquinone-7 Supplementation Improves Arterial Stiffness in Healthy Postmenopausal Women” is significant because it confirms what previous population-based studies have only been able to show an association, according to Cees Vermeer, renowned vitamin K2 scientist and chief innovation officer at the R&D Group VitaK of the Maastricht University Holding (the Netherlands), who led the study’s research team.
“This is the first study showing that long-term use of vitamin K2 in the form of MK-7 beneficially affects cardiovascular health,” says Vermeer.”
The VitaK research group included 244 healthy postmenopausal women for three years monitoring cardiovascular effects using pulse wave velocity and ultrasound techniques. The participants, aged 55 to 65 years, were randomly assigned to take 180 mcg of MenaQ7 daily for three years, or placebo capsules. Ninety-three percent of the participants completed the three-year study—an unusually good compliance for a nutritional study showing that daily intake of MenaQ7® vitamin K2 was safe and problem free. The study was approved by Medical Ethical Committee at Maastricht University and included in the international ClinicalsTrials.gov register.
Results confirmed that MenaQ7 Vitamin K2 not only inhibited age-related stiffening of the artery walls, but also made an unprecedented statistically significant improvement of vascular elasticity.
“The women taking the MenaQ7vitamin K2 did not experience the typical age-related progression of arterial wall stiffening, and even made a statistically significant improvement of vascular elasticity, compared to the placebo group,” Vermeer continues. “Our data demonstrated that a nutritional dose of vitamin K2 in fact improves cardiovascular outcomes.”
This same cohort was examined in another study proving MenaQ7’s bone benefits that published in Osteoporosis International in 2013.
“Both studies are significant because they are long-term—three years of participation and then examination of the results,” said Hogne Vik, NattoPharma CEO. “Observing changes in heart health, and bone health for that matter, take time. Our patience and perseverance has paid off with a study accepted by a highly prestigious medical journal that proves what we have known all along: that MenaQ7 Vitamin K2 truly delivers benefits for hearts and bones.”
“This cardiovascular study is significant because it shows that vitamin K2 not only benefits our bone health, but is also important to heart health,” said Dennis Goodman, MD, board-certified cardiologist and Director of Integrative Medicine at NYU Langone Medical Center in New York. “Vitamin K2 ensures calcium binds to the bone mineral matrix and stays out of the arteries.”
Dr. Goodman, who is completing a new book explaining the important role that vitamin K2 plays in achieving both bone and heart health, says flexibility of the arteries also has a direct connection to a person’s longevity. Calcification in the arteries has been shown to add 10 years to a person’s biological age, according to a study published in The New England Journal of Medicine (Rosenhek, et al., 2000). Another study published in the scientific journal Atherosclerosis (Shaw et al., vol. 188, 206) shows your biological age could decrease or increase by 10 years based on the level of age-related arterial calcification.
“This vitamin K2/MenaQ7 study, which is actually showing an improvement in arterial function, has the potential to dramatically impact the way we view prevention when it comes to cardiovascular health,” Goodman adds. “Further clinical studies will be important to confirm these exciting findings.”