Capros mitigates cold pressor stress

Capros mitigates cold pressor stress

New study suggests Natreon's CAPROS may help mitigate cold pressor stress–induced cardiovascular changes.

Natreon is pleased to announce the publication of a clinical study on CAPROS® in healthy volunteers subjected to cold pressor test, which is a cardiovascular test performed by immersing the hand into an ice water bath until pain is unbearable and measuring changes in cardiovascular pharmacodynamic parameters. This study demonstrated that CAPROS showed a significant decrease in the indices of arterial stiffness (augmentation index and radial and aortic blood pressures) and a significant increase in subendocardial viability ratio (SEVR), an index of myocardial perfusion, suggesting that CAPROS may help mitigate cold pressor stress–induced cardiovascular changes.

This is a double-blind, placebo-controlled, crossover clinical study. Twelve healthy volunteers were randomized to receive two capsules of 250 mg of CAPROS (a patented, GRAS affirmed, highly standardized Phyllanthus emblica extract containing Emblicanin-A, Emblicanin-B, Punigluconin and Pedunculagin as bioactives) BID or two matching placebo capsules BID for 14 days. Pharmacodynamic parameters such as heart rate, augmentation pressure, augmentation index (AIx), subendocardial viability ratio (SEVR), radial and aortic blood pressure (BP) were recorded before and after the cold pressor test at baseline and at the end of treatment. After a washout period of 14 days, subjects crossed over to the other treatment and the same test procedure was repeated. Safety assessments were done at baseline and at the end of treatment. This study was conducted by researchers at the Department of Clinical Pharmacology and Therapeutics at the Nizam’s Institute of Medical Sciences in Hyderabad, India and published in peer-reviewed journal Pharmacognosy Research, January-March 2014, Volume 6, Issue 1, pp 29-35.

“We are very excited with the results of this study which suggests that CAPROS may help people cope with cold stress–induced cardiovascular changes," said Natreon CEO Dr. Sanni Raju. "This study further substantiates the cardiovascular health benefits of CAPROS and is an excellent addition to the collection of studies which have been conducted to date. We look forward to the publication of several additional studies in the following months."


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