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Research Capsule: Aker BioMarine’s Superba Krill Oil, FutureCeuticals’ FruiteX-B® Calcium Fructoborate

Krill oil supplementation can potentially protect against ulcerative colitis; FruiteX-B may help alleviate symptoms of minor knee osteoarthritis.

Vital stats: Aker BioMarine’s Superba Krill Oil, omega-3 eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and the antioxidant astaxanthin

Study claim: Krill oil supplementation can potentially protect against ulcerative colitis, a form of inflammatory bowel disease, by providing antioxidant and anti-inflammatory benefits.

Published: Grimstad T, et al. Dietary supplementation of krill oil attenuates inflammation and oxidative stress in experimental ulcerative colitis in rats. Scand. J. Gastroenterol. 2012;47(1):49-58

Abstract: The University of Bergen, Norway conducted a four-week study using 30 male rats to test how krill oil supplementation affects ulcerative colitis, a bowel disease involving inflammation and sores in the gastrointestinal tract. Researchers divided the rats into three groups: a control group, a group with induced ulcerative colitis and a group with ulcerative colitis receiving krill oil supplementation.

Several measurements were taken to determine the effect of the krill oil, including the disease activity index (DAI), colon length, histological combined score (HCS), colon levels of certain cytokines and prostaglandins, markers of protein oxidative damage, and the fatty acid profile.

Levels of protein oxidative markers decreased significantly and colon length was substantially preserved in the krill oil supplementation group compared to the induced ulcerative colitis group. The supplementation group also consistently experienced beneficial changes with regards to the other measurements. These results indicate a potential for krill oil to have an anti-inflammatory and protein antioxidant effect.

Potential applications: The possible anti-inflammatory abilities of krill oil may be helpful in supplementing for other health concerns, such as joint discomfort and cardiovascular risk.

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Vital stats: FutureCeuticals’ FruiteX-B® Calcium Fructoborate, supplement combination of naturally sourced boron, calcium and fructose

Study claim: After supplementing with FruiteX-B, subjects with minor knee osteoarthritis experienced reduced pain and improved levels of CRP and 1,25(OH), two indicators of arthritis.

Published: Reyes-Izquierdo T, et al. Short-term intake of calcium fructoborate improves WOMAC and McGill Scores and beneficially modulates biomarkers associated with knee osteoarthritis: A pilot clinical double-blinded placebo-controlled study. Am. J. Biomed. Sci. 2012, doi: 10.5099/aj120200111

Abstract: In a double blind, placebo-controlled study, researchers tested the effect of FruiteX-B on patients with minor knee osteoarthritis. The 14-day study aimed to investigate whether supplementation with calcium fructoborate can reduce pain and stiffness and alter levels of C-Reactive Protein (CRP) and the active form of vitamin D, 1,25-Dihydroxy (1,25(OH)). Calcium Fructoborate is a compound found naturally and manufactured synthetically in the form of FruiteX-B.  High levels of CRP indicate inflammation and low levels of 1,25(OH) are commonly associated with arthritis. 

Researchers used the McGill Pain Questionnaire and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) to examine responses of patients supplementing with FruiteX-B. Supplementing subjects experienced major reductions in pain and stiffness and significantly improved physical function after seven days of testing. At the end of the study, the WOMAC and McGill scores improved by 29 percent and 14 percent respectively.

Researches also tested the blood levels of CRP and 1,25(OH) in patients supplementing with FruiteX-B and compared results to previously established baseline levels. By the end of the study, CRP reduced to 37 percent of baseline levels and 1,25(OH) blood levels increased an average of 19 percent above baseline.

Potential applications: This synthetic supplement form of calcium fructoborate can help treat symptoms of osteoarthritis and comes in capsule form.

More info:
[email protected]



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