Improved Mood Connected to Anti-Inflammatory Properties of Tibetan PADMA Formula

SANTA ROSA, Calif., November 29, 2004 - A new study that examines depressive mood changes in relation to positive effects of the Tibetan herbal formula, PADMA, further upholds Better Health Publishing's® information on Tibetan integrative therapies. The authors suggest that the PADMA formula has a dual benefit for people with chronic diseases: its previously proven anti-inflammatory, anti-oxidant and immunobiological effects as well as an improved mood-state. (1)

This study, performed at Austria's Innsbruck Medical University, examines earlier clinical research of PADMA's effects on intermittent claudication, an arterial dysfunction that leads to painful legs while walking, atherosclerosis and chronic hepatitis B. (2) Additional earlier findings reported PADMA as having an anti-inflammatory affect on parts of the immune system, specifically on the cykotine network, the hormone-like proteins produced by white blood cells that act as messengers between cells. The intermittent claudication study found that participants reported feelings of increased well-being after taking PADMA.

The current study's findings point to a possible mechanism that explains the previously reported mood changes in association with PADMA treatment. The effects of the PADMA formula were observed in incubated human peripheral blood mononuclear cells (PBMC), a type of human immune cells. Levels of neopterin, a substance that indicates the level of immune system activation and anti-inflammation, and tryptophan, an essential amino acid that plays an important role in mood regulation, were measured within PADMA-stimulated and unstimulated cells. Results show that neopterin levels in stimulated cells decreased, while tryptophan levels increased. Neopterin levels are important for signaling the presence of chronic diseases; high levels can indicate the presence of inflammatory disease, viral infections and rejection from grafts. Tryptophan levels mark the amount of essential amino acids and are connected to the mood-regulating melatonin and serotonin hormones, which play important roles in human health conditions such as mental health.

"This study highlights PADMA and its complex effects on the immune system and depressive mood-state and is extremely relevant to the ever-expanding benefits of Tibetan medicine," states Isaac Eliaz, M.D., L.Ac., founder of Better Health Publishing and medical director of Amitabha Medical Clinic and Healing Center.

PADMA is a multi-compound Tibetan herbal formula that consists of 21 compounds: 19 herbal ingredients, camphor and calcium sulphate. Additional studies have suggested that the PADMA formula may be effective in promoting healthy circulation and improving cardiovascular and vein health. PADMA is sold as a drug and as a nutritional supplement in Europe. PADMA is also sold as a nutritional supplement in North America.

Better Health Publishing,, a Santa Rosa education-based company, is dedicated to providing responsible information and updates of scientific research on integrative therapies to health care professionals and individuals interested in self-care.

For more information on PADMA and Tibetan medicine contact Better Health Publishing at 800.521.0160 or For additional inquiries or to request a copy of the study contact Amanda Holty at [email protected] or 801.538.0777 ext. 106.

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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

(1) Uberall, et al. Chronic inflammation: Modulation of the cytokine network by PADMA 28. GanzheitsMedizin 2004; 16(360-2).

(2) Neurauter G, et al. PADMA 28 modulates interferon-gamma-induced tryptophan degradation and neopterin production in human PBMC in vitro.
International Immunopharmacology 2004;4:833-9.

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