New Study Shows GliSODin(R) Inhibits DNA Damage Due to Ischemia-reperfusion Induced Oxidative Stress

MORRISTOWN, NJ (March 1, 2005) PL Thomas (PLT) today announced the results of a new study using its exclusive dietary supplement ingredient, GliSODin®, recently presented at the 11th Congress of the European Shock Society in Vienna, Austria. The study was conducted by a team of researchers at the University of Ulm, Germany.

This study looked at ischemia-reperfusion injury, which can be a concern during surgery, caused by the restriction and reintroduction of blood flow. The generation of oxygen-derived radicals has been demonstrated to be the major mechanism of ischemia-reperfusion induced oxidative damage.

The authors concluded that in this in vivo study, “The Orally Effective Mixture of Sod and Gliadin (GliSODin®) Protects Against Oxidative DNA Damage,” pretreatment with the new nutritional formula GliSODin inhibits oxidative DNA damage related to induced ischemia-reperfusion injury.

Previously, the researchers have shown that GliSODin protects against induced oxidative damage in a double-blind, placebo-controlled clinical trial that was published in Free Radical Research, September 2004.1

The positive results prompted the researchers to further investigate whether GliSODin is also protective when used during more severe oxidative stress, including that caused by surgery and ischemia-reperfusion.

In this animal study, swine were given GliSODin or placebo, and DNA damage was evaluated in blood samples before and after hyperbaric-oxygen induced oxidative stress, using a measure of DNA strand breaks. The GliSODin group demonstrated significant DNA protection compared to placebo.

DNA strand breaks were then used to evaluate DNA damage induced by ischemia-reperfusion. During thoracic aortic surgery, whole blood samples were taken before thoracic aortic cross-clamping, 30 minutes after clamping, and two and four hours after declamping.

GliSODin reduced oxidative DNA damage related to surgical stress and ischemia-reperfusion after aortic clamping compared to placebo, resulting in a statistically significant difference two hours after declamping. Finally, isoprostane levels, another marker of oxidative stress, increased in both hepatic venous and portal venous samples of the placebo group, but not in the GliSODin group.

1Muth, et. al. "Influence of an orally effective SOD on hyperbaric, oxygen related cell damage,” Free Radical Research 38:9 (2004) pp. 927-932

About GliSODin

GliSODin® is patented and trademarked by Isocell, Paris, France. It is available in North America as a nutritional raw material exclusively from PL Thomas & Co., Morristown, NJ. Numerous animal and human studies support the use of GliSODin in nutritional applications. These include: Immune support, Sports Nutrition, and Antioxidant.

About PLT

PL Thomas & Co., a New Jersey-based ingredient supplier, offers fifty years of innovation in securing reliable, high quality raw materials for the food/functional food and nutrition industries.

For more information contact: PL Thomas & Co., 119 Headquarters Plaza, Morristown, NJ 07960, phone: 973-984-0900, fax: 973-984-5666, e-mail: [email protected] or

# # #

Eric Anderson
PL Thomas
Phone: 973-984-0900 x 215
Email: [email protected]

Hide comments


  • Allowed HTML tags: <em> <strong> <blockquote> <br> <p>

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.