Nutrition 21’s Diachrome™ Ingredient System Found to Improve Cholesterol Profiles in People with Type 2 Diabetes

PURCHASE, N.Y., April 15, 2003 –The results of a double-blind, placebo-controlled clinical study testing the benefits of Diachrome™ were presented yesterday at the Experimental Biology 2003 meeting in San Diego. The study showed that the company’s proprietary ingredient combination, Diachrome (chromium picolinate and biotin), significantly improved cholesterol profiles in people with type 2 diabetes. Improvements in cholesterol profiles are of great importance to the 17 million people with diabetes in the U.S. for whom the leading cause of death is heart disease.

In this study, 34 participants with type 2 diabetes were randomized to receive a nutritional beverage fortified with Diachrome, or the same beverage without Diachrome, for 12 weeks. The group receiving the beverage containing Diachrome revealed significant decreases in total cholesterol and LDL-cholesterol, and increases in the healthy HDL form of cholesterol, compared to the control group.

“The cardiovascular benefits seen in the study are significant for people with diabetes,” states Dr. Vijaya Juturu, Nutrition Scientist, Nutrition 21, Inc. “In light of the fact that so many Americans have type 2 diabetes and are at risk for cardiovascular complications, we are encouraged by the cholesterol improvements achieved by those participants who received the beverage fortified with Diachrome,” added Dr. Juturu.

Many experts in metabolic research speculate that Western diets rich in highly refined carbohydrate-laden foods and beverages are contributing to the epidemic rise in the worldwide incidence of obesity and type 2 diabetes associated with insulin resistance. It is estimated that 95 million Americans have some degree of insulin resistance and that 800,000 new cases of diabetes are diagnosed every year.

Clinical markers for the metabolic syndrome (sometimes called insulin resistance syndrome) established by the National Institutes of Health (NIH) include elevated LDL, decreased HDL and elevated triglycerides. While earlier studies have demonstrated that Diachrome can attenuate glycemic response to carbohydrate-rich beverages in people with diabetes, these new findings indicate that Diachrome fortification may also reduce risk factors for cardiovascular disease. “Both findings should be of importance to formulators and manufacturers in the $136 billion U.S. carbonated soft drink and juice markets who are concerned about the metabolic impact of sugar consumption, particularly in populations at risk for these diseases,” says Gail Montgomery, President and CEO of Nutrition 21, Inc.

Nutrtion 21 provided funding for the study and supplied the proprietary Diachrome™ ingredient system used in the fortified beverage formulation.

About Nutrition 21

Nutrition 21 is a leading developer and provider of nutritional products whose health benefits are substantiated by clinical research. The market leader in nutritional chromium, Nutrition 21 currently holds 35 patents for nutrition products, 22 for chromium compounds and their uses. More information is available at

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