Researchers at the University of Montana announced results from a recent in vitro study on a standardized extract of Bacopa monnieri, a plant used widely and historically in the traditional Indian system of Ayurveda to enhance cognitive health, memory, and mood.
The results were presented at a poster session at the annual meeting of the American Society of Pharmacognosy on July 24 at Oregon State University in Corvallis, Oregon. Keith Parker, PhD. and Rustem Medora, Ph.D., coauthors of the project, were present at the poster session.
While previous in vitro studies on Bacopa focus on the neurotransmitters GABA and acetylcholine, this study provides direct evidence that Bacopa can also regulate the activity of specific serotonin receptors. The study concluded that the Bacopa extract displaces antagonist [3H]Ketanserin from serotonin receptor 5HT2a isolated from rats, and exhibited even stronger effects in its displacement of agonist 8-OH-DPAT from the 5HT1a receptor.
The study also concluded that the Bacopa extract decreases cAMP production in cells with 5HT1a receptors, suggesting it causes an agonistic effect. This effect was similar to results from a previous study where Bacopa displayed antidepressant effects comparable to imipramine.
The primary active components unique to Bacopa, called bacosides, have been isolated. Bacosides have recently been shown to help regulate protein kinase activity and increase new protein synthesis, specifically in cells from parts of the brain associated with long-term memory.
The Bacopa extract used in the study is made by Geni Herbs of Noblesville, Indiana, and marketed as BaCognize®, a patent-pending botanical ingredient for use in dietary supplements.
This study may spark new interest in the research of plants such as Bacopa to provide a natural way to maximize cognitive function in situations where it may be compromised.
Geni Herbs, an innovative manufacturer of botanical extracts, continues to meet the growing consumer demand for natural, science-backed ingredients that maintain balanced health. From complete control of cultivation and manufacturing, to individualized technical services, customers enjoy a range of benefits beyond GH’s full line of standardized botanical extracts, functional ingredients, and nutraceuticals.