A recent study by the Dutch company OrgaNext Research found that activated vitamin D stimulates expression of the androgen receptor in skeletal muscle cells. The researchers also found that nandrolone, the active metabolite of the anabolic steroid nandrolon decanoate, stimulates expression of the vitamin D receptor in skeletal muscle cells and that the combination of nandrolone and hydroxylated vitamin D (NDD) has a synergistic effect on the in-vitro proliferation of human skeletal muscle cells. The Dutch scientist Lenus Kloosterboer, PhD, presented these breakthrough findings in Boston, USA, during the Annual Meeting of the Endocrine Society (June 4-8, 2011).
Kloosterboer: “We found that both compounds stimulate expression of their own and each other receptors in human skeletal muscle. This has never been published before and could help unravel the mechanism of action of muscle regeneration.
What makes this study unique is that both young and aged human skeletal muscle cells were used. However, the receptor expression was greater in the aged muscle cells. It is likely that the number of both the androgen receptor and the vitamin D receptor on human skeletal muscle lower as we age, which may be why muscle regeneration slows down as people grow older. It is really promising that we were able to demonstrate that the proliferation of satellite cells, also known as new skeletal muscle cells, can be triggered by the active metabolites of NDD.
Muscle mass plays a key role in recovery from illness or trauma. Hospitalized elderly patients can lose up to 10% of lean leg muscle mass in only three days and there remains a substantial unmet medical need to support the recovery of these patients.
The results of this study may help us understand the underlying mechanisms of human muscle regeneration and bring us closer to offering a clinical solution.”
About OrgaNext Research
OrgaNext Research BV is a Dutch biopharmaceutical company focused on the development of medicines that help people to recover physical strength after hospitalization and injury. It is a privately owned company, founded by former Organon and Unilever executives in 2009. More information: http://www.organext.com.