New Research Shows Combination of Tomato Phytonutrients Effectively Combats Breast Cancer

Poster Presentation at AACR Conference will Discuss How Lycopene Alone is Not as

Effective as Combination of Tomato Phytonutrients



New research conducted by Dr. Joseph Levy and Dr. Yoav Sharoni of the Faculty of Health Sciences, Ben-Gurion University and Soroka Medical Center in Be’er Sheva, Israel, is more proof that tomato lycopene in combination with other tomato phytonutrients is more effective in treating breast cancer than lycopene alone. This new research follows on the heels and parallels the results of their earlier research on LNCap human prostate cancer cells. (Figure 1)

Dr. Levy will conduct a poster presentation featuring an abstract of this study at the upcoming American Association for Cancer Research (AACR) Conference, to be held October 14-18, 2002 in Boston, Massachusetts. The abstract will also be published in AACR’s October 2002 Journal.

Using an in vitro model of MCF-7 human breast cancer cells, Drs. Levy and Sharoni incubated the cells with a combination of low concentrations of the tomato carotenoids phytoene, phytofluene and lycopene. These low concentrations reflect the blood concentrations found in Europeans or Americans with low intake of tomato products. The cancer cell proliferation decreased dramatically in the breast cancer cell sample treated with this complex of tomato phytonutrients.

Moreover, Drs. Levy and Sharoni found that breast cancer cells that were treated with the same low concentration 0.3mM/liter of lycopene alone showed no significant decrease in proliferation. The same dramatic inhibition of cancer cells achieved by the combination of tomato phytonutrients, can be obtained when using lycopene alone, but only in the higher concentrations of 2mM/liter. Since such high lycopene levels in the blood are not found in humans, high supplemental therapeutic doses of lycopene alone will not provide practical benefit to cancer patients. (Figure 2)

In summary, the research of Dr. Levy and Sharoni suggests that the therapeutic benefits of the tomato come from Mother Nature’s complex synergy of tomato phytonutrients and not from any one phytonutrient in isolation.

This natural combination of tomato lycopene, phytoene, and phytofluene is found in the standardized tomato extract Lyc-O-Mato®. For more information, visit the company’s web site at

Media Note: Lyc-O-Mato® is a registered trademark of LycoRed Natural Products Ltd., Israel To arrange an interview with Dr. Heber or to obtain a full copy of the study manuscript, please contact Media Relations at (800) 999-4859. Additional information is available at or and 1-866-Lyc-O-Mato.


Figure 1

Figure 2

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